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10.1089/ars.2016.6695 http://scihub22266oqcxt.onion/10.1089/ars.2016.6695 C5098128!5098128!26983461     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26983461&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antioxid+Redox+Signal 2016 ; 25 (14): 758-74 Nephropedia Template TP {{tp|p=26983461|t=2016. Epigenetic Regulation of Monocyte and Macrophage Function |pdf=|usr=}}{{26983461}} gab.com Text Epigenetic Regulation of Monocyte and Macrophage Function JO: Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=26983461 #FOAvip Significance: Monocytes and macrophages are key players in tissue homeostasis and immune responses. Epigenetic processes tightly regulate cellular functioning in health and disease. Recent Advances: Recent technical developments have allowed detailed characterizations of the transcriptional circuitry underlying monocyte and macrophage regulation. Upon differentiation and activation, enhancers are selected by lineage-determining and signal-dependent transcription factors. Enhancers are shown to be very dynamic and activation of these enhancers underlies the differences in gene transcription between monocytes and macrophages and their subtypes. Critical Issues: It has been shown that epigenetic enzymes regulate the functioning of these cells and targeting of epigenetic enzymes has been proven to be a valuable tool to dampen inflammatory responses. We give a comprehensive overview of recent developments and understanding of the epigenetic pathways that control monocyte and macrophage function and of the epigenetic enzymes involved in monocyte and macrophage differentiation and activation. Future Directions: The key challenges in the upcoming years will be to study epigenetic changes in human disease and to better understand how epigenetic pathways control the inflammatory repertoire in disease. Antioxid. Redox Signal. 25, 758?774. Twit Text FOAVip Epigenetic Regulation of Monocyte and Macrophage Function ????Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=26983461 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26983461 #FOAvip English Wikipedia <ref>{{Cite pmid|26983461}}</ref> Epigenetic Regulation of Monocyte and Macrophage Function #MMPMID26983461 Hoeksema MA; de Winther MP Antioxid Redox Signal 2016[Nov]; 25 (14): 758-74 PMID26983461show ga Significance: Monocytes and macrophages are key players in tissue homeostasis and immune responses. Epigenetic processes tightly regulate cellular functioning in health and disease. Recent Advances: Recent technical developments have allowed detailed characterizations of the transcriptional circuitry underlying monocyte and macrophage regulation. Upon differentiation and activation, enhancers are selected by lineage-determining and signal-dependent transcription factors. Enhancers are shown to be very dynamic and activation of these enhancers underlies the differences in gene transcription between monocytes and macrophages and their subtypes. Critical Issues: It has been shown that epigenetic enzymes regulate the functioning of these cells and targeting of epigenetic enzymes has been proven to be a valuable tool to dampen inflammatory responses. We give a comprehensive overview of recent developments and understanding of the epigenetic pathways that control monocyte and macrophage function and of the epigenetic enzymes involved in monocyte and macrophage differentiation and activation. Future Directions: The key challenges in the upcoming years will be to study epigenetic changes in human disease and to better understand how epigenetic pathways control the inflammatory repertoire in disease. Antioxid. Redox Signal. 25, 758?774. äEpigenetic Regulation of Monocyte and Macrophage Function (epmc).pdf DeepDyve Pubget Overpricing