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2016 ; 2016
(ä): 5162394
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The Biomechanics and Optimization of the Needle-Syringe System for Injecting
Triamcinolone Acetonide into Keloids
#MMPMID27843936
Vo A
; Doumit M
; Rockwell G
J Med Eng
2016[]; 2016
(ä): 5162394
PMID27843936
show ga
Purpose. Injecting triamcinolone acetonide (TA) into a keloid is physically
challenging due to the density of keloids. The purpose was to investigate the
effects of various syringe and needle combinations on the injection force to
determine the most ergonomic combination. Materials and Methods. A load cell was
used to generate and measure the injection force. Phase 1: the injection force of
5 common syringes was measured by injecting water into air. The syringe that
required the lowest injection force was evaluated with various needle gauges (25,
27, and 30?G) and lengths (16, 25, and 38?mm) by injecting TA (40?mg/mL) into
air. The needle-syringe combination with the lowest injection force (CLIF) was
deemed the most ergonomic combination. Phase 2: comparisons between the CLIF and
a standard combination (SC) were performed by injecting TA into air and tap water
into a keloid specimen. Intraclass Correlation Coefficient (ICC) and independent
t-test were used. Results. Increasing the syringe caliber, injection speed, and
needle gauge and length significantly increased the injection force (p value <
0.001). The SC required a maximum force of 40.0?N to inject water into keloid,
compared to 25.0?N for the CLIF. Injecting TA into keloid using the SC would
require an injection force that was 103.5% of the maximum force female thumbs
could exert compared to 64.8% for the CLIF. ICC values were greater than 0.4.
Conclusions. The 1?mL polycarbonate syringe with a 25?G, 16?mm needle (CLIF) was
the most ergonomic combination. The SC required a substantial injection force,
which may represent a physical challenge for female thumbs.