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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Toxicol+Pathol
2016 ; 29
(4
): 261-264
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Acute alloxan toxicity causes granulomatous tubulointerstitial nephritis with
severe mineralization
#MMPMID27821911
Zhang L
; Terayama Y
; Nishimoto T
; Kodama Y
; Ozaki K
J Toxicol Pathol
2016[Oct]; 29
(4
): 261-264
PMID27821911
show ga
Alloxan had been recognized as having a direct nephrotoxic effect different from
its diabetogenic action. We encountered previously unreported granulomatous
tubulointerstitial nephritis with severe luminal and interstitial mineralization
in one diabetic rat after one week of alloxan administration.
Histopathologically, many dilated and occluded proximal and distal tubules were
segmentally observed in the cortex and outer medulla. The tubular lumen contained
minerals and cell debris. Tubular epithelial cells were degenerated and piled up,
and they protruded into the lumen, where they enveloped minerals. Mineralization
was observed mainly in the tubular lumen, and to some extent in the subepithelium
and interstitium. The mineralization beneath the tubular epithelium was often
continuous from the subepithelium to the interstitium. In these lesions, the
tubular basement membrane was disrupted by mineralization, and a granuloma with
multinuclear foreign-body giant cells was formed in the interstitial areas.