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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Toxicol+Pathol
2016 ; 29
(4
): 247-252
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Quercetin inhibited cadmium-induced autophagy in the mouse kidney via inhibition
of oxidative stress
#MMPMID27821909
Yuan Y
; Ma S
; Qi Y
; Wei X
; Cai H
; Dong L
; Lu Y
; Zhang Y
; Guo Q
J Toxicol Pathol
2016[Oct]; 29
(4
): 247-252
PMID27821909
show ga
The objective of the current study was to explore the inhibitory effects of
quercetin on cadmium-induced autophagy in mouse kidneys. Mice were
intraperitoneally injected with cadmium and quercetin once daily for 3 days. The
LC3-II/?-actin ratio was used as the autophagy marker, and autophagy was observed
by transmission electron microscopy. Oxidative stress was investigated in terms
of reactive oxygen species, total antioxidant capacity, and malondialdehyde.
Cadmium significantly induced typical autophagosome formation, increased the
LC3-II/?-actin ratio, reactive oxygen species level, and malondialdehyde content,
and decreased total antioxidant capacity. Interestingly, quercetin markedly
decreased the cadmium-induced LC3-II/?-actin ratio, reactive oxygen species
levels, and malondialdehyde content, and simultaneously increased total
antioxidant capacity. Cadmium can inhibit total antioxidant capacity, produce a
large amount of reactive oxygen species, lead to oxidative stress, and promote
lipid peroxidation, eventually inducing autophagy in mouse kidneys. Quercetin
could inhibit cadmium-induced autophagy via inhibition of oxidative stress. This
study may provide a theoretical basis for the treatment of cadmium injury.