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10.1155/2016/2048987 http://scihub22266oqcxt.onion/10.1155/2016/2048987 C5097791!5097791!27843938     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2016 ; 2016 (ä): ä Nephropedia Template TP {{tp|p=27843938|t=2016. Wnt-?-Catenin Signaling Promotes the Maturation of Mast Cells |pdf=|usr=}}{{27843938}} gab.com Text Wnt- -Catenin Signaling Promotes the Maturation of Mast Cells JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=27843938 #FOAvip Mast cells play an important role in the pathogenesis of allergic diseases. Immature mast cells migrate into peripheral tissues from the bone marrow and undergo complete maturation. Interestingly, mast cells have characteristics similar to hematopoietic stem cells (HSCs), such as self-renewal and c-kit expression. In HSCs, Wnt signaling is involved in their maintenance and differentiation. On the other hand, the relation between Wnt signaling and mast cell differentiation is poorly understood. To study whether Wnt signals play a role in the maturation of mast cells, we studied the effect of Wnt proteins on mast cell maturation of bone marrow-derived mast cells (BMMCs). The expression levels of CD81 protein and histidine decarboxylase mRNA and activity of mast cell-specific protease were all elevated in BMMCs treated with Wnt5a. In addition, Wnt5a induced the expression of Axin2 and TCF mRNA in BMMCs. These results showed that Wnt5a could promote the maturation of mast cells via the canonical Wnt signaling pathway and provide important insights into the molecular mechanisms underlying the differentiation of mast cells. Twit Text FOAVip Wnt- -Catenin Signaling Promotes the Maturation of Mast Cells ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=27843938 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27843938 #FOAvip English Wikipedia <ref>{{Cite pmid|27843938}}</ref> Wnt-?-Catenin Signaling Promotes the Maturation of Mast Cells #MMPMID27843938 Yamaguchi T; Nishijima M; Tashiro K; Kawabata K Biomed Res Int 2016[]; 2016 (ä): ä PMID27843938show ga Mast cells play an important role in the pathogenesis of allergic diseases. Immature mast cells migrate into peripheral tissues from the bone marrow and undergo complete maturation. Interestingly, mast cells have characteristics similar to hematopoietic stem cells (HSCs), such as self-renewal and c-kit expression. In HSCs, Wnt signaling is involved in their maintenance and differentiation. On the other hand, the relation between Wnt signaling and mast cell differentiation is poorly understood. To study whether Wnt signals play a role in the maturation of mast cells, we studied the effect of Wnt proteins on mast cell maturation of bone marrow-derived mast cells (BMMCs). The expression levels of CD81 protein and histidine decarboxylase mRNA and activity of mast cell-specific protease were all elevated in BMMCs treated with Wnt5a. In addition, Wnt5a induced the expression of Axin2 and TCF mRNA in BMMCs. These results showed that Wnt5a could promote the maturation of mast cells via the canonical Wnt signaling pathway and provide important insights into the molecular mechanisms underlying the differentiation of mast cells. äWnt-?-Catenin Signaling Promotes the Maturation of Mast Cells (epmc).pdf DeepDyve Pubget Overpricing