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10.1016/j.stem.2016.08.001 http://scihub22266oqcxt.onion/10.1016/j.stem.2016.08.001 C5097006!5097006 !27618218     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27618218 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Stem+Cell 2016 ; 19 (5 ): 628-642 Nephropedia Template TP {{tp|p=27618218 |t=2016. Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease |pdf=|usr=}}{{27618218 }} gab.com Text Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=27618218 #FOAvip Mesenchymal stem cell (MSC)-like cells reside in the vascular wall, but their role in vascular regeneration and disease is poorly understood. Here, we show that Gli1(+) cells located in the arterial adventitia are progenitors of vascular smooth muscle cells and contribute to neointima formation and repair after acute injury to the femoral artery. Genetic fate tracing indicates that adventitial Gli1(+) MSC-like cells migrate into the media and neointima during athero- and arteriosclerosis in ApoE(-/-) mice with chronic kidney disease. Our data indicate that Gli1(+) cells are a major source of osteoblast-like cells during calcification in the media and intima. Genetic ablation of Gli1(+) cells before induction of kidney injury dramatically reduced the severity of vascular calcification. These findings implicate Gli1(+) cells as critical adventitial progenitors in vascular remodeling after acute and during chronic injury and suggest that they may be relevant therapeutic targets for mitigation of vascular calcification. Twit Text FOAVip Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=27618218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27618218 #FOAvip English Wikipedia <ref>{{Cite pmid|27618218 }}</ref> Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease #MMPMID27618218 Kramann R ; Goettsch C ; Wongboonsin J ; Iwata H ; Schneider RK ; Kuppe C ; Kaesler N ; Chang-Panesso M ; Machado FG ; Gratwohl S ; Madhurima K ; Hutcheson JD ; Jain S ; Aikawa E ; Humphreys BD Cell Stem Cell 2016[Nov]; 19 (5 ): 628-642 PMID27618218 show ga Mesenchymal stem cell (MSC)-like cells reside in the vascular wall, but their role in vascular regeneration and disease is poorly understood. Here, we show that Gli1(+) cells located in the arterial adventitia are progenitors of vascular smooth muscle cells and contribute to neointima formation and repair after acute injury to the femoral artery. Genetic fate tracing indicates that adventitial Gli1(+) MSC-like cells migrate into the media and neointima during athero- and arteriosclerosis in ApoE(-/-) mice with chronic kidney disease. Our data indicate that Gli1(+) cells are a major source of osteoblast-like cells during calcification in the media and intima. Genetic ablation of Gli1(+) cells before induction of kidney injury dramatically reduced the severity of vascular calcification. These findings implicate Gli1(+) cells as critical adventitial progenitors in vascular remodeling after acute and during chronic injury and suggest that they may be relevant therapeutic targets for mitigation of vascular calcification. |Adventitia/*pathology [MESH] |Aged [MESH] |Animals [MESH] |Antigens, CD34/metabolism [MESH] |Ataxin-1/metabolism [MESH] |Biomarkers/metabolism [MESH] |Cell Dedifferentiation [MESH] |Cell Differentiation [MESH] |Cell Lineage [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Female [MESH] |Hedgehog Proteins/metabolism [MESH] |Humans [MESH] |Male [MESH] |Mesenchymal Stem Cells/metabolism/*pathology [MESH] |Mice, Transgenic [MESH] |Muscle, Smooth, Vascular/*pathology [MESH] |Myocytes, Smooth Muscle/metabolism/*pathology [MESH] |Neointima/pathology [MESH] |Osteoblasts/metabolism/pathology [MESH] |Plaque, Atherosclerotic/pathology [MESH] |Receptor, Platelet-Derived Growth Factor beta/metabolism [MESH] |Renal Insufficiency, Chronic/*complications/pathology [MESH] |Stem Cells/*pathology [MESH] |Vascular Calcification/*complications/pathology [MESH] |Vascular Remodeling [MESH]Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle C(epmc).pdf DeepDyve Pubget Overpricing