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10.1172/JCI87492 http://scihub22266oqcxt.onion/10.1172/JCI87492 C5096925!5096925!27669462     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest ä ; 126 (11): 4103-18 Nephropedia Template TP {{tp|p=27669462|t=ä. Mast cell desensitization inhibits calcium flux and aberrantly remodels actin |pdf=|usr=}}{{27669462}} gab.com Text Mast cell desensitization inhibits calcium flux and aberrantly remodels actin JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27669462 #FOAvip Rush desensitization (DS) is a widely used and effective clinical strategy for the rapid inhibition of IgE-mediated anaphylactic responses. However, the cellular targets and underlying mechanisms behind this process remain unclear. Recent studies have implicated mast cells (MCs) as the primary target cells for DS. Here, we developed a murine model of passive anaphylaxis with demonstrated MC involvement and an in vitro assay to evaluate the effect of DS on MCs. In contrast with previous reports, we determined that functional IgE remains on the cell surface of desensitized MCs following DS. Despite notable reductions in MC degranulation following DS, the high-affinity IgE receptor Fc?RI was still capable of transducing signals in desensitized MCs. Additionally, we found that displacement of the actin cytoskeleton and its continued association with Fc?RI impede the capacity of desensitized MCs to evoke the calcium response that is essential for MC degranulation. Together, these findings suggest that reduced degranulation responses in desensitized MCs arise from aberrant actin remodeling, providing insights that may lead to improvement of DS treatments for anaphylactic responses. Twit Text FOAVip Mast cell desensitization inhibits calcium flux and aberrantly remodels actin ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=27669462 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27669462 #FOAvip English Wikipedia <ref>{{Cite pmid|27669462}}</ref> Mast cell desensitization inhibits calcium flux and aberrantly remodels actin #MMPMID27669462 Ang WG; Church AM; Kulis M; Choi HW; Burks AW; Abraham SN J Clin Invest ä[]; 126 (11): 4103-18 PMID27669462show ga Rush desensitization (DS) is a widely used and effective clinical strategy for the rapid inhibition of IgE-mediated anaphylactic responses. However, the cellular targets and underlying mechanisms behind this process remain unclear. Recent studies have implicated mast cells (MCs) as the primary target cells for DS. Here, we developed a murine model of passive anaphylaxis with demonstrated MC involvement and an in vitro assay to evaluate the effect of DS on MCs. In contrast with previous reports, we determined that functional IgE remains on the cell surface of desensitized MCs following DS. Despite notable reductions in MC degranulation following DS, the high-affinity IgE receptor Fc?RI was still capable of transducing signals in desensitized MCs. Additionally, we found that displacement of the actin cytoskeleton and its continued association with Fc?RI impede the capacity of desensitized MCs to evoke the calcium response that is essential for MC degranulation. Together, these findings suggest that reduced degranulation responses in desensitized MCs arise from aberrant actin remodeling, providing insights that may lead to improvement of DS treatments for anaphylactic responses. äMast cell desensitization inhibits calcium flux and aberrantly remodel(epmc).pdf DeepDyve Pubget Overpricing