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2016 ; 94
(11
): 841-849
Nephropedia Template TP
gab.com Text
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Times to key events in Zika virus infection and implications for blood donation:
a systematic review
#MMPMID27821887
Lessler J
; Ott CT
; Carcelen AC
; Konikoff JM
; Williamson J
; Bi Q
; Kucirka LM
; Cummings DA
; Reich NG
; Chaisson LH
Bull World Health Organ
2016[Nov]; 94
(11
): 841-849
PMID27821887
show ga
OBJECTIVE: To estimate the timing of key events in the natural history of Zika
virus infection. METHODS: In February 2016, we searched PubMed, Scopus and the
Web of Science for publications containing the term Zika. By pooling data, we
estimated the incubation period, the time to seroconversion and the duration of
viral shedding. We estimated the risk of Zika virus contaminated blood donations.
FINDINGS: We identified 20 articles on 25 patients with Zika virus infection. The
median incubation period for the infection was estimated to be 5.9 days (95%
credible interval, CrI: 4.4-7.6), with 95% of people who developed symptoms doing
so within 11.2 days (95% CrI: 7.6-18.0) after infection. On average,
seroconversion occurred 9.1 days (95% CrI: 7.0-11.6) after infection. The virus
was detectable in blood for 9.9 days (95% CrI: 6.9-21.4) on average. Without
screening, the estimated risk that a blood donation would come from an infected
individual increased by approximately 1 in 10 000 for every 1 per
100 000 person-days increase in the incidence of Zika virus infection.
Symptom-based screening may reduce this rate by 7% (relative risk, RR: 0.93; 95%
CrI: 0.89-0.99) and antibody screening, by 29% (RR: 0.71; 95% CrI: 0.28-0.88).
CONCLUSION: Neither symptom- nor antibody-based screening for Zika virus
infection substantially reduced the risk that blood donations would be
contaminated by the virus. Polymerase chain reaction testing should be considered
for identifying blood safe for use in pregnant women in high-incidence areas.