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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Transplant
2016 ; 16
(11
): 3282-3285
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Successful Transplantation of Human Kidneys Deemed Untransplantable but
Resuscitated by Ex Vivo Normothermic Machine Perfusion
#MMPMID27273794
Hosgood SA
; Saeb-Parsy K
; Hamed MO
; Nicholson ML
Am J Transplant
2016[Nov]; 16
(11
): 3282-3285
PMID27273794
show ga
We report the successful transplantation of a pair of human kidneys that were
declined for transplantation due to inadequate in situ perfusion but subsequently
transplanted after perfusion and assessment using ex vivo normothermic perfusion
(EVNP). The kidneys were from a 35-year-old man, a donation after circulatory
death donor. Both kidneys were declined by all UK transplant centers. On arrival,
the kidneys had significant areas of incomplete clearance of blood from the
microcirculation that did not clear after a further attempt to flush them.
Kidneys underwent 60 min of EVNP with an oxygenated packed red blood cell-based
solution warmed to 35.2°C. During EVNP, the patchy areas cleared in both kidneys.
The mean renal blood flow and total urine output were 68.0 mL/min/100 g and 560
mL in the left kidney and 59.9 mL/min/100 g, 430 mL in the right, respectively.
Based on the EVNP perfusion parameters, both kidneys were deemed suitable for
transplantation. They were transplanted without any complications, and both
recipients had initial graft function. The serum creatinine levels at 3 months
were 1.2 mg/dl in the recipient of the left kidney and 1.62 mg/dl in the
recipient of the right kidney. EVNP technology can be used to assess and rescue
kidneys previously deemed unsuitable for transplantation.