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10.1111/dom.12698 http://scihub22266oqcxt.onion/10.1111/dom.12698 C5096008!5096008!27265390     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes+Obes+Metab 2016 ; 18 (11): 1081-8 Nephropedia Template TP {{tp|p=27265390|t=2016. Randomized, double?blind clinical trial comparing basal insulin peglispro and insulin glargine, in combination with prandial insulin lispro, in patients with type 1 diabetes: IMAGINE 3 |pdf=|usr=}}{{27265390}} gab.com Text Randomized, double blind clinical trial comparing basal insulin peglispro and insulin glargine, in combination with prandial insulin lispro, in patients with type 1 diabetes: IMAGINE 3 JO: Diabetes Obes Metab http://www.kidney.de/pget.php?&tw=1&pmid=27265390 #FOAvip Aims: To compare the efficacy and safety of basal insulin peglispro (BIL), which has a flat pharmacokinetic and pharmacodynamic profile and a long duration of action, with insulin glargine (GL) in patients with type 1 diabetes. Materials and methods: In this phase III, 52?week, blinded study, we randomized 1114 adults with type 1 diabetes in a 3?:?2 distribution to receive either BIL (n?=?664) or GL (n?=?450) at bedtime, with preprandial insulin lispro, using intensive insulin management. The primary objective was to compare glycated haemoglobin (HbA1c) in the groups at 52?weeks, with a non?inferiority margin of 0.4%. Results: At 52?weeks, mean (standard error) HbA1c was 7.38 (0.03)% with BIL and 7.61 (0.04)% with GL {difference ?0.22% [95% confidence interval (CI) ?0.32, ?0.12]; p?<?0.001}. At 52?weeks more BIL?treated patients reached HbA1c <7% (35% vs 26%; p?<?0.001), the nocturnal hypoglycaemia rate was 47% lower (p?<?0.001) and the total hypoglycaemia rate was 11% higher (p?=?0.002) than in GL?treated patients, and there was no difference in severe hypoglycaemia rate. Patients receiving BIL lost weight, while those receiving GL gained weight [difference ?1.8?kg (95% CI ?2.3, ?1.3); p?<?0.001]. Treatment with BIL compared with GL at 52?weeks was associated with greater increases from baseline in levels of serum triglyceride [difference 0.19?mmol/l (95% CI 0.11, 0.26); p?<?0.001] and alanine aminotransferase (ALT) levels [difference 6.5 IU/l (95% CI 4.1, 8.9), p?<?0.001], and more frequent injection site reactions. Conclusions: In patients with type 1 diabetes, treatment with BIL compared with GL for 52?weeks resulted in a lower HbA1c, more patients with HbA1c levels <7%, and reduced nocturnal hypoglycaemia, but more total hypoglycaemia and injection site reactions and higher triglyceride and ALT levels. Twit Text FOAVip Randomized, double blind clinical trial comparing basal insulin peglispro and insulin glargine, in combination with prandial insulin lispro, in patients with type 1 diabetes: IMAGINE 3 ????Diabetes Obes Metab http://www.kidney.de/pget.php?&tw=1&pmid=27265390 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27265390 #FOAvip English Wikipedia <ref>{{Cite pmid|27265390}}</ref> Randomized, double?blind clinical trial comparing basal insulin peglispro and insulin glargine, in combination with prandial insulin lispro, in patients with type 1 diabetes: IMAGINE 3 #MMPMID27265390 Bergenstal RM; Lunt H; Franek E; Travert F; Mou J; Qu Y; Antalis CJ; Hartman ML; Rosilio M; Jacober SJ; Bastyr EJ Diabetes Obes Metab 2016[Nov]; 18 (11): 1081-8 PMID27265390show ga Aims: To compare the efficacy and safety of basal insulin peglispro (BIL), which has a flat pharmacokinetic and pharmacodynamic profile and a long duration of action, with insulin glargine (GL) in patients with type 1 diabetes. Materials and methods: In this phase III, 52?week, blinded study, we randomized 1114 adults with type 1 diabetes in a 3?:?2 distribution to receive either BIL (n?=?664) or GL (n?=?450) at bedtime, with preprandial insulin lispro, using intensive insulin management. The primary objective was to compare glycated haemoglobin (HbA1c) in the groups at 52?weeks, with a non?inferiority margin of 0.4%. Results: At 52?weeks, mean (standard error) HbA1c was 7.38 (0.03)% with BIL and 7.61 (0.04)% with GL {difference ?0.22% [95% confidence interval (CI) ?0.32, ?0.12]; p? äRandomized, double?blind clinical trial comparing basal insulin peglis(epmc).pdf DeepDyve Pubget Overpricing