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10.1186/s40478-016-0386-4 http://scihub22266oqcxt.onion/10.1186/s40478-016-0386-4 C5096005!5096005!27809932     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Neuropathol+Commun 2016 ; 4 (ä): ä Nephropedia Template TP {{tp|p=27809932|t=2016. Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies |pdf=|usr=}}{{27809932}} gab.com Text Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies JO: Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=27809932 #FOAvip A given cell makes exchanges with its neighbors through a variety of means ranging from diffusible factors to vesicles. Cells use also tunneling nanotubes (TNTs), filamentous-actin-containing membranous structures that bridge and connect cells. First described in immune cells, TNTs facilitate HIV-1 transfer and are found in various cell types, including neurons. We show that the microtubule-associated protein Tau, a key player in Alzheimer?s disease, is a bona fide constituent of TNTs. This is important because Tau appears beside filamentous actin and myosin 10 as a specific marker of these fine protrusions of membranes and cytosol that are difficult to visualize. Furthermore, we observed that exogenous Tau species increase the number of TNTs established between primary neurons, thereby facilitating the intercellular transfer of Tau fibrils. In conclusion, Tau may contribute to the formation and function of the highly dynamic TNTs that may be involved in the prion-like propagation of Tau assemblies.Electronic supplementary material: The online version of this article (doi:10.1186/s40478-016-0386-4) contains supplementary material, which is available to authorized users. Twit Text FOAVip Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies ????Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=27809932 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27809932 #FOAvip English Wikipedia <ref>{{Cite pmid|27809932}}</ref> Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies #MMPMID27809932 Tardivel M; Bégard S; Bousset L; Dujardin S; Coens A; Melki R; Buée L; Colin M Acta Neuropathol Commun 2016[]; 4 (ä): ä PMID27809932show ga A given cell makes exchanges with its neighbors through a variety of means ranging from diffusible factors to vesicles. Cells use also tunneling nanotubes (TNTs), filamentous-actin-containing membranous structures that bridge and connect cells. First described in immune cells, TNTs facilitate HIV-1 transfer and are found in various cell types, including neurons. We show that the microtubule-associated protein Tau, a key player in Alzheimer?s disease, is a bona fide constituent of TNTs. This is important because Tau appears beside filamentous actin and myosin 10 as a specific marker of these fine protrusions of membranes and cytosol that are difficult to visualize. Furthermore, we observed that exogenous Tau species increase the number of TNTs established between primary neurons, thereby facilitating the intercellular transfer of Tau fibrils. In conclusion, Tau may contribute to the formation and function of the highly dynamic TNTs that may be involved in the prion-like propagation of Tau assemblies.Electronic supplementary material: The online version of this article (doi:10.1186/s40478-016-0386-4) contains supplementary material, which is available to authorized users. äTunneling nanotube (TNT)-mediated neuron-to neuron transfer of patholo(epmc).pdf DeepDyve Pubget Overpricing