Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/science.1258236 http://scihub22266oqcxt.onion/10.1126/science.1258236 C5095928!5095928!25477468     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2014 ; 346 (6214): 1258236 Nephropedia Template TP {{tp|p=25477468|t=2014. An ancient defense system eliminates unfit cells from developing tissues during cell competition |pdf=|usr=}}{{25477468}} gab.com Text An ancient defense system eliminates unfit cells from developing tissues during cell competition JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=25477468 #FOAvip Developing tissues that contain mutant or compromised cells present risks to animal health. Accordingly, the appearance of a population of suboptimal cells in a tissue elicits cellular interactions that prevent their contribution to the adult. Here we report that this quality control process, cell competition, uses specific components of the evolutionarily ancient and conserved innate immune system to eliminate Drosophila cells perceived as unfit. We find that Toll-related receptors (TRRs) and the cytokine Spätzle (Spz) lead to NF?B-dependent apoptosis. Diverse ?loser? cells require different TRRs and NF?B factors and activate distinct pro-death genes, implying that the particular response is stipulated by the competitive context. Our findings demonstrate a functional repurposing of components of TRRs and NF?B signaling modules in the surveillance of cell fitness during development. Twit Text FOAVip An ancient defense system eliminates unfit cells from developing tissues during cell competition ????Science http://www.kidney.de/pget.php?&tw=1&pmid=25477468 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25477468 #FOAvip English Wikipedia <ref>{{Cite pmid|25477468}}</ref> An ancient defense system eliminates unfit cells from developing tissues during cell competition #MMPMID25477468 Meyer SN; Amoyel M; Bergantiņos C; de la Cova C; Schertel C; Basler K; Johnston LA Science 2014[Dec]; 346 (6214): 1258236 PMID25477468show ga Developing tissues that contain mutant or compromised cells present risks to animal health. Accordingly, the appearance of a population of suboptimal cells in a tissue elicits cellular interactions that prevent their contribution to the adult. Here we report that this quality control process, cell competition, uses specific components of the evolutionarily ancient and conserved innate immune system to eliminate Drosophila cells perceived as unfit. We find that Toll-related receptors (TRRs) and the cytokine Spätzle (Spz) lead to NF?B-dependent apoptosis. Diverse ?loser? cells require different TRRs and NF?B factors and activate distinct pro-death genes, implying that the particular response is stipulated by the competitive context. Our findings demonstrate a functional repurposing of components of TRRs and NF?B signaling modules in the surveillance of cell fitness during development. äAn ancient defense system eliminates unfit cells from developing tissu(epmc).pdf DeepDyve Pubget Overpricing