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10.1042/BST20160116 http://scihub22266oqcxt.onion/10.1042/BST20160116 C5095913!5095913!27911707     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Soc+Trans 2016 ; 44 (5): 1253-63 Nephropedia Template TP {{tp|p=27911707|t=2016. The PLK4?STIL?SAS-6 module at the core of centriole duplication |pdf=|usr=}}{{27911707}} gab.com Text The PLK4 STIL SAS-6 module at the core of centriole duplication JO: Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=27911707 #FOAvip Centrioles are microtubule-based core components of centrosomes and cilia. They are duplicated exactly once during S-phase progression. Central to formation of each new (daughter) centriole is the formation of a nine-fold symmetrical cartwheel structure onto which microtubule triplets are deposited. In recent years, a module comprising the protein kinase polo-like kinase 4 (PLK4) and the two proteins STIL and SAS-6 have been shown to stay at the core of centriole duplication. Depletion of any one of these three proteins blocks centriole duplication and, conversely, overexpression causes centriole amplification. In this short review article, we summarize recent insights into how PLK4, STIL and SAS-6 co-operate in space and time to form a new centriole. These advances begin to shed light on the very first steps of centriole biogenesis. Twit Text FOAVip The PLK4 STIL SAS-6 module at the core of centriole duplication ????Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=27911707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27911707 #FOAvip English Wikipedia <ref>{{Cite pmid|27911707}}</ref> The PLK4?STIL?SAS-6 module at the core of centriole duplication #MMPMID27911707 Arquint C; Nigg EA Biochem Soc Trans 2016[Oct]; 44 (5): 1253-63 PMID27911707show ga Centrioles are microtubule-based core components of centrosomes and cilia. They are duplicated exactly once during S-phase progression. Central to formation of each new (daughter) centriole is the formation of a nine-fold symmetrical cartwheel structure onto which microtubule triplets are deposited. In recent years, a module comprising the protein kinase polo-like kinase 4 (PLK4) and the two proteins STIL and SAS-6 have been shown to stay at the core of centriole duplication. Depletion of any one of these three proteins blocks centriole duplication and, conversely, overexpression causes centriole amplification. In this short review article, we summarize recent insights into how PLK4, STIL and SAS-6 co-operate in space and time to form a new centriole. These advances begin to shed light on the very first steps of centriole biogenesis. äThe PLK4?STIL?SAS-6 module at the core of centriole duplication (epmc).pdf DeepDyve Pubget Overpricing