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10.1042/BCJ20160010 http://scihub22266oqcxt.onion/10.1042/BCJ20160010 C5095910!5095910!27679854     free     free     free       Biochem+J 2016 ; 473 (19): 2911-35 Nephropedia Template TP {{tp|p=27679854|t=2016. The role of TREX in gene expression and disease |pdf=|usr=}}{{27679854}} gab.com Text The role of TREX in gene expression and disease JO: Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=27679854 #FOAvip TRanscription and EXport (TREX) is a conserved multisubunit complex essential for embryogenesis, organogenesis and cellular differentiation throughout life. By linking transcription, mRNA processing and export together, it exerts a physiologically vital role in the gene expression pathway. In addition, this complex prevents DNA damage and regulates the cell cycle by ensuring optimal gene expression. As the extent of TREX activity in viral infections, amyotrophic lateral sclerosis and cancer emerges, the need for a greater understanding of TREX function becomes evident. A complete elucidation of the composition, function and interactions of the complex will provide the framework for understanding the molecular basis for a variety of diseases. This review details the known composition of TREX, how it is regulated and its cellular functions with an emphasis on mammalian systems. Twit Text FOAVip The role of TREX in gene expression and disease ????Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=27679854 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27679854 #FOAvip English Wikipedia <ref>{{Cite pmid|27679854}}</ref> The role of TREX in gene expression and disease #MMPMID27679854 Heath CG; Viphakone N; Wilson SA Biochem J 2016[Oct]; 473 (19): 2911-35 PMID27679854show ga TRanscription and EXport (TREX) is a conserved multisubunit complex essential for embryogenesis, organogenesis and cellular differentiation throughout life. By linking transcription, mRNA processing and export together, it exerts a physiologically vital role in the gene expression pathway. In addition, this complex prevents DNA damage and regulates the cell cycle by ensuring optimal gene expression. As the extent of TREX activity in viral infections, amyotrophic lateral sclerosis and cancer emerges, the need for a greater understanding of TREX function becomes evident. A complete elucidation of the composition, function and interactions of the complex will provide the framework for understanding the molecular basis for a variety of diseases. This review details the known composition of TREX, how it is regulated and its cellular functions with an emphasis on mammalian systems. äThe role of TREX in gene expression and disease (epmc).pdf DeepDyve Pubget Overpricing