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10.1002/ijc.30406 http://scihub22266oqcxt.onion/10.1002/ijc.30406 C5095795!5095795 !27561100     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27561100 &cmd=llinks): Failed to open stream: HTTP request failed! 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Alternating electric fields (TTFields) in combination with paclitaxel are therapeutically effective against ovarian cancer cells in vitro and in vivo |pdf=|usr=}}{{27561100 }} gab.com Text Alternating electric fields (TTFields) in combination with paclitaxel are therapeutically effective against ovarian cancer cells in vitro and in vivo JO: Int J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27561100 #FOAvip Long-term survival rates for advanced ovarian cancer patients have not changed appreciably over the past four decades; therefore, development of new, effective treatment modalities remains a high priority. Tumor Treating Fields (TTFields), a clinically active anticancer modality utilize low-intensity, intermediate frequency, alternating electric fields. The goal of this study was to evaluate the efficacy of combining TTFields with paclitaxel against ovarian cancer cells in vitro and in vivo. In vitro application of TTFields on human ovarian cancer cell lines led to a significant reduction in cell counts as compared to untreated cells. The effect was found to be frequency and intensity dependent. Further reduction in the number of viable cells was achieved when TTFields treatment was combined with paclitaxel. The in vivo effect of the combined treatment was tested in mice orthotopically implanted with MOSE-L(TICv) cells. In this model, combined treatment led to a significant reduction in tumor luminescence and in tumor weight as compared to untreated mice. The feasibility of effective local delivery of TTFields to the human abdomen was examined using finite element mesh simulations performed using the Sim4life software. These simulations demonstrated that electric fields intensities inside and in the vicinity of the ovaries of a realistic human computational phantom are about 1 and 2 V/cm pk-pk, respectively, which is within the range of intensities required for TTFields effect. These results suggest that prospective clinical investigation of the combination of TTFields and paclitaxel is warranted. Twit Text FOAVip Alternating electric fields (TTFields) in combination with paclitaxel are therapeutically effective against ovarian cancer cells in vitro and in vivo ????Int J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27561100 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27561100 #FOAvip English Wikipedia <ref>{{Cite pmid|27561100 }}</ref> Alternating electric fields (TTFields) in combination with paclitaxel are therapeutically effective against ovarian cancer cells in vitro and in vivo #MMPMID27561100 Voloshin T ; Munster M ; Blatt R ; Shteingauz A ; Roberts PC ; Schmelz EM ; Giladi M ; Schneiderman RS ; Zeevi E ; Porat Y ; Bomzon Z ; Urman N ; Itzhaki A ; Cahal S ; Kirson ED ; Weinberg U ; Palti Y Int J Cancer 2016[Dec]; 139 (12 ): 2850-2858 PMID27561100 show ga Long-term survival rates for advanced ovarian cancer patients have not changed appreciably over the past four decades; therefore, development of new, effective treatment modalities remains a high priority. Tumor Treating Fields (TTFields), a clinically active anticancer modality utilize low-intensity, intermediate frequency, alternating electric fields. The goal of this study was to evaluate the efficacy of combining TTFields with paclitaxel against ovarian cancer cells in vitro and in vivo. In vitro application of TTFields on human ovarian cancer cell lines led to a significant reduction in cell counts as compared to untreated cells. The effect was found to be frequency and intensity dependent. Further reduction in the number of viable cells was achieved when TTFields treatment was combined with paclitaxel. The in vivo effect of the combined treatment was tested in mice orthotopically implanted with MOSE-L(TICv) cells. In this model, combined treatment led to a significant reduction in tumor luminescence and in tumor weight as compared to untreated mice. The feasibility of effective local delivery of TTFields to the human abdomen was examined using finite element mesh simulations performed using the Sim4life software. These simulations demonstrated that electric fields intensities inside and in the vicinity of the ovaries of a realistic human computational phantom are about 1 and 2 V/cm pk-pk, respectively, which is within the range of intensities required for TTFields effect. These results suggest that prospective clinical investigation of the combination of TTFields and paclitaxel is warranted. |Animals [MESH] |Antineoplastic Agents/*pharmacology [MESH] |Cell Line, Tumor [MESH] |Cell Survival/drug effects/radiation effects [MESH] |Combined Modality Therapy [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Humans [MESH] |Mice [MESH] |Ovarian Neoplasms/diagnostic imaging/*pathology/therapy [MESH] |Paclitaxel/*pharmacology [MESH] |Treatment Outcome [MESH]Alternating electric fields (TTFields) in combination with paclitaxel (epmc).pdf DeepDyve Pubget Overpricing