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10.1182/blood-2016-01-692855

http://scihub22266oqcxt.onion/10.1182/blood-2016-01-692855
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C5095757!5095757!27670423
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suck abstract from ncbi


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pmid27670423      Blood 2016 ; 128 (18): 2229-40
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  • High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia #MMPMID27670423
  • Chiang MY; Wang Q; Gormley AC; Stein SJ; Xu L; Shestova O; Aster JC; Pear WS
  • Blood 2016[Nov]; 128 (18): 2229-40 PMID27670423show ga
  • Notch1 mutations are selected in the murine T-ALL model despite genetic pan-Notch inhibition; other pathways do not easily substitute it.Myc is the key Notch target responsible for Notch-selective pressure in T-ALL as it can substitute for Notch; by contrast, Akt cannot.
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