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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 World+J+Gastrointest+Pharmacol+Ther
2016 ; 7
(4
): 550-555
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gab.com Text
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English Wikipedia
Usefulness of vonoprazan, a potassium ion-competitive acid blocker, for primary
eradication of Helicobacter pylori
#MMPMID27867688
Yamada S
; Kawakami T
; Nakatsugawa Y
; Suzuki T
; Fujii H
; Tomatsuri N
; Nakamura H
; Sato H
; Okuyama Y
; Kimura H
; Yoshida N
World J Gastrointest Pharmacol Ther
2016[Nov]; 7
(4
): 550-555
PMID27867688
show ga
AIM: To investigate usefulness of triple therapy with vonoprazan, a potassium
ion-competitive acid blocker and antibiotics, for Helicobacter pylori (H. pylori)
eradication. METHODS: The H. pylori eradication rate was examined in 2507
patients (2055 undergoing primary eradication and 452 undergoing secondary
eradication, excluding patients with subtotal gastrectomy) at the Japanese Red
Cross Kyoto Daiichi Hospital from March 2013 to September 2015. For patients
treated from March 2013 to February 2015, a proton pump inhibitor (PPI) was used
to reduce acid secretion, while vonoprazan was used after March 2015. The success
rates of the 2 regimens (PPI + amoxicillin + clarithromycin/metronidazole, or
vonoprazan + amoxicillin + clarithromycin/metronidazole) were compared. RESULTS:
The success rate of primary H. pylori eradication was significantly higher in the
vonoprazan group. When stratified by the underlying disease, a significant
increase of the H. pylori eradication rate was observed in patients with chronic
gastritis. A significantly lower H. pylori eradication rate was observed in
younger patients compared to older patients in the PPI group, but there was no
difference according to age in the vonoprazan group. On the other hand, the
success rate of secondary eradication was similar at approximately 90% in both
groups. CONCLUSION: Vonoprazan is very useful for primary eradication of H.
pylori, and may become a first-line acid secretion inhibitor instead of PPIs.