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http://scihub22266oqcxt.onion/ C5095300!5095300!27829991     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transl+Res 2016 ; 8 (10): 4040-53 Nephropedia Template TP {{tp|p=27829991|t=2016. P53 inhibitor pifithrin-? prevents the renal tubular epithelial cells against injury |pdf=|usr=}}{{27829991}} gab.com Text P53 inhibitor pifithrin- prevents the renal tubular epithelial cells against injury JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=27829991 #FOAvip The injury and repair of renal tubular epithelial cells play an important role in the pathological process of acute kidney injury (AKI). This study aimed to clarify the role of cell cycle change in renal tubular epithelial cell injury and repair in vivo and in vitro. Sprague-Dawley rats received bilateral renal pedicle clamping for 45 min (ischemia) followed by reperfusion. Pifithrin-?, a p53 inhibitor, was administered at 24 h before renal ischemia and 3 and 14 days after reperfusion. Results showed the tubular epithelial cells in M phase increased significantly at 2 h to 72 h after ischemia/reperfusion (I/R), while pifithrin-? decreased them. Renal I/R caused renal tubular epithelial damage in rats, which was improved by pifithrin-?. The ?-SMA mRNA expression was up-regulated significantly after I/R, while it was down-regulated by pifithrin-?.NRK-52E cells were cultured in vitro, cell damage was induced by addition of TNF-?, and then cells were treated with pifithrin-?. Cells treated with TNF-? alone in G2/M phase increased significantly, but they were reduced in the presence of pifithrin-?. In NRK-52E cells treated with pifithrin-? for 6 h, NGAL mRNA expression was significantly lower than in cells without pifithrin-? treatment. After NRK-52E cells were treated with pifithrin-? for 24 h, ?-SMA and FN mRNA expression was significantly lower than in cells without the treatment. In summary, pifithrin-? can facilitate the progression of renal tubular epithelial cells through G2/M phase, protecting them against injury. Twit Text FOAVip P53 inhibitor pifithrin- prevents the renal tubular epithelial cells against injury ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=27829991 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27829991 #FOAvip English Wikipedia <ref>{{Cite pmid|27829991}}</ref> P53 inhibitor pifithrin-? prevents the renal tubular epithelial cells against injury #MMPMID27829991 Shen YL; Sun L; Hu YJ; Liu HJ; Kuang XY; Niu XL; Huang WY Am J Transl Res 2016[]; 8 (10): 4040-53 PMID27829991show ga The injury and repair of renal tubular epithelial cells play an important role in the pathological process of acute kidney injury (AKI). This study aimed to clarify the role of cell cycle change in renal tubular epithelial cell injury and repair in vivo and in vitro. Sprague-Dawley rats received bilateral renal pedicle clamping for 45 min (ischemia) followed by reperfusion. Pifithrin-?, a p53 inhibitor, was administered at 24 h before renal ischemia and 3 and 14 days after reperfusion. Results showed the tubular epithelial cells in M phase increased significantly at 2 h to 72 h after ischemia/reperfusion (I/R), while pifithrin-? decreased them. Renal I/R caused renal tubular epithelial damage in rats, which was improved by pifithrin-?. The ?-SMA mRNA expression was up-regulated significantly after I/R, while it was down-regulated by pifithrin-?.NRK-52E cells were cultured in vitro, cell damage was induced by addition of TNF-?, and then cells were treated with pifithrin-?. Cells treated with TNF-? alone in G2/M phase increased significantly, but they were reduced in the presence of pifithrin-?. In NRK-52E cells treated with pifithrin-? for 6 h, NGAL mRNA expression was significantly lower than in cells without pifithrin-? treatment. After NRK-52E cells were treated with pifithrin-? for 24 h, ?-SMA and FN mRNA expression was significantly lower than in cells without the treatment. In summary, pifithrin-? can facilitate the progression of renal tubular epithelial cells through G2/M phase, protecting them against injury. äP53 inhibitor pifithrin-? prevents the renal tubular epithelial cells (epmc).pdf DeepDyve Pubget Overpricing