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10.1210/jc.2016-1963 http://scihub22266oqcxt.onion/10.1210/jc.2016-1963 C5095258!5095258!27428770     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Endocrinol+Metab 2016 ; 101 (11): 3989-96 Nephropedia Template TP {{tp|p=27428770|t=2016. Dietary Sodium Restriction Increases the Risk of Misinterpreting Mild Cases of Primary Aldosteronism |pdf=|usr=}}{{27428770}} gab.com Text Dietary Sodium Restriction Increases the Risk of Misinterpreting Mild Cases of Primary Aldosteronism JO: J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=27428770 #FOAvip Context:: The aldosterone to renin ratio (ARR) is recommended to screen for primary aldosteronism (PA). Objective:: To evaluate whether dietary sodium restriction results in misinterpretation of PA screening. Participants:: Untreated hypertensives with ARR more than 20 on a high dietary sodium intake (HS) were also evaluated on a low dietary sodium intake (LS) (n = 241). Positive screening for PA was defined as: plasma renin activity (PRA) less than or equal to 1.0 ng/mL · h with serum aldosterone more than or equal to 6 ng/dL. PA was confirmed by a 24-hour urinary aldosterone excretion more than or equal to 12 mcg with urinary sodium more than 200 mmol. Results:: Only 33% (79/241) of participants with an ARR more than 20 had a positive PA screen on HS. On LS, 56% (44/79) of these participants no longer met criteria for positive PA screening. When compared with participants with positive PA screening on both diets, participants with a positive screen on HS but negative on LS exhibited a significantly higher PRA on both diets. Remarkably, of the 48/79 participants who had PA confirmed, 52% had negative PA screening on LS. The distinguishing feature of these participants with ?discordant? screening results was a larger rise in PRA on LS resulting in normalization of the ARR and higher Caucasian race prevalence. Conclusions:: Sodium restriction is recommended in hypertension; however, it can significantly raise PRA, normalize the ARR, and result in false interpretation of PA screening. Milder phenotypes of PA, where PRA is not as suppressed, are most susceptible to dietary sodium influences on renin and ARR. Optimal screening for PA should occur under conditions of HS. Twit Text FOAVip Dietary Sodium Restriction Increases the Risk of Misinterpreting Mild Cases of Primary Aldosteronism ????J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=27428770 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27428770 #FOAvip English Wikipedia <ref>{{Cite pmid|27428770}}</ref> Dietary Sodium Restriction Increases the Risk of Misinterpreting Mild Cases of Primary Aldosteronism #MMPMID27428770 Baudrand R; Guarda FJ; Torrey J; Williams G; Vaidya A J Clin Endocrinol Metab 2016[Nov]; 101 (11): 3989-96 PMID27428770show ga Context:: The aldosterone to renin ratio (ARR) is recommended to screen for primary aldosteronism (PA). Objective:: To evaluate whether dietary sodium restriction results in misinterpretation of PA screening. Participants:: Untreated hypertensives with ARR more than 20 on a high dietary sodium intake (HS) were also evaluated on a low dietary sodium intake (LS) (n = 241). Positive screening for PA was defined as: plasma renin activity (PRA) less than or equal to 1.0 ng/mL · h with serum aldosterone more than or equal to 6 ng/dL. PA was confirmed by a 24-hour urinary aldosterone excretion more than or equal to 12 mcg with urinary sodium more than 200 mmol. Results:: Only 33% (79/241) of participants with an ARR more than 20 had a positive PA screen on HS. On LS, 56% (44/79) of these participants no longer met criteria for positive PA screening. When compared with participants with positive PA screening on both diets, participants with a positive screen on HS but negative on LS exhibited a significantly higher PRA on both diets. Remarkably, of the 48/79 participants who had PA confirmed, 52% had negative PA screening on LS. The distinguishing feature of these participants with ?discordant? screening results was a larger rise in PRA on LS resulting in normalization of the ARR and higher Caucasian race prevalence. Conclusions:: Sodium restriction is recommended in hypertension; however, it can significantly raise PRA, normalize the ARR, and result in false interpretation of PA screening. Milder phenotypes of PA, where PRA is not as suppressed, are most susceptible to dietary sodium influences on renin and ARR. Optimal screening for PA should occur under conditions of HS. äDietary Sodium Restriction Increases the Risk of Misinterpreting Mild (epmc).pdf DeepDyve Pubget Overpricing