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10.1038/ncomms13187 http://scihub22266oqcxt.onion/10.1038/ncomms13187 C5095173!5095173 !27782102     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27782102 &cmd=llinks): Failed to open stream: HTTP request failed! 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Disulfide-activated protein kinase G I? regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response |pdf=|usr=}}{{27782102 }} gab.com Text Disulfide-activated protein kinase G I regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27782102 #FOAvip The Frank-Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and oxidants are produced. Here we show that protein kinase G I? (PKGI?) is oxidant-activated during stretch and this form of the kinase selectively phosphorylates cardiac phospholamban Ser16-a site important for diastolic relaxation. We find that hearts of Cys42Ser PKGI? knock-in (KI) mice, which are resistant to PKGI? oxidation, have diastolic dysfunction and a diminished ability to couple ventricular filling with cardiac output on a beat-to-beat basis. Intracellular calcium dynamics of ventricular myocytes isolated from KI hearts are altered in a manner consistent with impaired relaxation and contractile function. We conclude that oxidation of PKGI? during myocardial stretch is crucial for diastolic relaxation and fine-tunes the Frank-Starling response. Twit Text FOAVip Disulfide-activated protein kinase G I regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27782102 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27782102 #FOAvip English Wikipedia <ref>{{Cite pmid|27782102 }}</ref> Disulfide-activated protein kinase G I? regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response #MMPMID27782102 Scotcher J ; Prysyazhna O ; Boguslavskyi A ; Kistamas K ; Hadgraft N ; Martin ED ; Worthington J ; Rudyk O ; Rodriguez Cutillas P ; Cuello F ; Shattock MJ ; Marber MS ; Conte MR ; Greenstein A ; Greensmith DJ ; Venetucci L ; Timms JF ; Eaton P Nat Commun 2016[Oct]; 7 (ä): 13187 PMID27782102 show ga The Frank-Starling mechanism allows the amount of blood entering the heart from the veins to be precisely matched with the amount pumped out to the arterial circulation. As the heart fills with blood during diastole, the myocardium is stretched and oxidants are produced. Here we show that protein kinase G I? (PKGI?) is oxidant-activated during stretch and this form of the kinase selectively phosphorylates cardiac phospholamban Ser16-a site important for diastolic relaxation. We find that hearts of Cys42Ser PKGI? knock-in (KI) mice, which are resistant to PKGI? oxidation, have diastolic dysfunction and a diminished ability to couple ventricular filling with cardiac output on a beat-to-beat basis. Intracellular calcium dynamics of ventricular myocytes isolated from KI hearts are altered in a manner consistent with impaired relaxation and contractile function. We conclude that oxidation of PKGI? during myocardial stretch is crucial for diastolic relaxation and fine-tunes the Frank-Starling response. |Animals [MESH] |Biomechanical Phenomena [MESH] |Calcium-Binding Proteins/genetics/metabolism [MESH] |Calcium/metabolism [MESH] |Cardiac Output/physiology [MESH] |Cyclic GMP-Dependent Protein Kinase Type I/*genetics/metabolism [MESH] |Diastole/*physiology [MESH] |Disulfides/chemistry [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation [MESH] |Gene Knock-In Techniques [MESH] |Heart Ventricles/cytology/*enzymology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Myocardial Contraction/physiology [MESH] |Myocardium/cytology/*enzymology [MESH] |Myocytes, Cardiac/cytology/*enzymology [MESH] |Organ Culture Techniques [MESH] |Oxidation-Reduction [MESH] |Oxidative Stress [MESH] |Phosphorylation [MESH] |Primary Cell Culture [MESH] |Serine/metabolism [MESH]Disulfide-activated protein kinase G I? regulates cardiac diastolic re(epmc).pdf DeepDyve Pubget Overpricing