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10.18632/oncotarget.9287 http://scihub22266oqcxt.onion/10.18632/oncotarget.9287 C5095067!5095067 !27184007     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27184007 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mouse double minute 2 (MDM2) upregulates Snail expression and induces epithelial-to-mesenchymal transition in breast cancer cells in vitro and in vivo |pdf=|usr=}}{{27184007 }} gab.com Text Mouse double minute 2 (MDM2) upregulates Snail expression and induces epithelial-to-mesenchymal transition in breast cancer cells in vitro and in vivo JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27184007 #FOAvip The oncogene, mouse double minute 2 (MDM2), has been implicated in the pathogenesis of numerous cancers. In this study, we investigated the role of MDM2 in epithelial-to-mesenchymal transition (EMT) and the underlying mechanisms in breast cancer cells in vitro and in vivo. The results showed that up-regulation of MDM2 in MCF-7 cells altered the cell morphology to a mesenchymal phenotype. Knockdown of MDM2 in MDA-MB-231 cells altered the cell morphology to the epithelial phenotype. In addition, overexpression of MDM2 increased the expression of N-cadherin and Vimentin and decreased the expression of E-cadherin, at both the mRNA and protein levels, in vitro and in vivo. Conversely, down-regulation of MDM2 decreased the expression of N-cadherin and Vimentin, and increased the expression of E-cadherin in vitro. Furthermore, MDM2 up-regulated both the mRNA and protein expression of Snail in vitro and in vivo. Knockdown of Snail almost abolished MDM2 induced EMT in vitro. Finally, we found that MDM2 expression correlated with EMT markers and Snail: Snail expression was inversely associated with E-cadherin in human breast cancer samples. Our findings demonstrated that MDM2 induces EMT by enhancing Snail expression in vitro and in vivo. Thus, MDM2 may be a potential target for therapy against human metastatic breast cancer. Twit Text FOAVip Mouse double minute 2 (MDM2) upregulates Snail expression and induces epithelial-to-mesenchymal transition in breast cancer cells in vitro and in vivo ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27184007 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27184007 #FOAvip English Wikipedia <ref>{{Cite pmid|27184007 }}</ref> Mouse double minute 2 (MDM2) upregulates Snail expression and induces epithelial-to-mesenchymal transition in breast cancer cells in vitro and in vivo #MMPMID27184007 Lu X ; Yan C ; Huang Y ; Shi D ; Fu Z ; Qiu J ; Yin Y Oncotarget 2016[Jun]; 7 (24 ): 37177-37191 PMID27184007 show ga The oncogene, mouse double minute 2 (MDM2), has been implicated in the pathogenesis of numerous cancers. In this study, we investigated the role of MDM2 in epithelial-to-mesenchymal transition (EMT) and the underlying mechanisms in breast cancer cells in vitro and in vivo. The results showed that up-regulation of MDM2 in MCF-7 cells altered the cell morphology to a mesenchymal phenotype. Knockdown of MDM2 in MDA-MB-231 cells altered the cell morphology to the epithelial phenotype. In addition, overexpression of MDM2 increased the expression of N-cadherin and Vimentin and decreased the expression of E-cadherin, at both the mRNA and protein levels, in vitro and in vivo. Conversely, down-regulation of MDM2 decreased the expression of N-cadherin and Vimentin, and increased the expression of E-cadherin in vitro. Furthermore, MDM2 up-regulated both the mRNA and protein expression of Snail in vitro and in vivo. Knockdown of Snail almost abolished MDM2 induced EMT in vitro. Finally, we found that MDM2 expression correlated with EMT markers and Snail: Snail expression was inversely associated with E-cadherin in human breast cancer samples. Our findings demonstrated that MDM2 induces EMT by enhancing Snail expression in vitro and in vivo. Thus, MDM2 may be a potential target for therapy against human metastatic breast cancer. |*Gene Expression Regulation, Neoplastic [MESH] |Animals [MESH] |Antigens, CD/metabolism [MESH] |Biomarkers, Tumor/genetics/metabolism [MESH] |Breast Neoplasms/*genetics/pathology [MESH] |Cadherins/metabolism [MESH] |Down-Regulation [MESH] |Epithelial-Mesenchymal Transition/*genetics [MESH] |Female [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |MCF-7 Cells [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Proto-Oncogene Proteins c-mdm2/genetics/*metabolism [MESH] |RNA, Messenger/metabolism [MESH] |RNA, Small Interfering/genetics [MESH] |Snail Family Transcription Factors/*genetics/metabolism [MESH] |Tissue Array Analysis [MESH] |Up-Regulation [MESH] |Vimentin/metabolism [MESH]Mouse double minute 2 (MDM2) upregulates Snail expression and induces (epmc).pdf DeepDyve Pubget Overpricing