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10.18632/oncotarget.9191 http://scihub22266oqcxt.onion/10.18632/oncotarget.9191 C5095040!5095040!27167110     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (24): 36800-13 Nephropedia Template TP {{tp|p=27167110|t=2016. C-terminus of MUC16 activates Wnt signaling pathway through its interaction with ?-catenin to promote tumorigenesis and metastasis |pdf=|usr=}}{{27167110}} gab.com Text C-terminus of MUC16 activates Wnt signaling pathway through its interaction with -catenin to promote tumorigenesis and metastasis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27167110 #FOAvip MUC16/CA125 has been identified as a prominent cancer biomarker, especially for epithelial ovarian cancers, in clinical test for over three decades. Due to its huge mass, limited knowledge of MUC16 was acquired previously. By utilizing a well characterized self-made MUC16 monoclonal antibody, we identified the endogenous interaction between a C-terminal fragment of MUC16 (MUC16C) and ?-catenin for the first time, and further elucidated that trans-activation domain of ?-catenin is required for this interaction. Such interaction could activate the Wnt/?-catenin signaling pathway by facilitating cytosol-nucleus transportation of ?-catenin, consequently induce cell proliferation and the migration, eventually lead to tumorigenesis and metastasis in nude mice. Consistently, knockdown of MUC16 significantly weakened the capabilities of cells for proliferation and migration. Based on our discovery, we suggest that MUC16 appears as an attractive target for the development of effective anticancer drugs. Twit Text FOAVip C-terminus of MUC16 activates Wnt signaling pathway through its interaction with -catenin to promote tumorigenesis and metastasis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27167110 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27167110 #FOAvip English Wikipedia <ref>{{Cite pmid|27167110}}</ref> C-terminus of MUC16 activates Wnt signaling pathway through its interaction with ?-catenin to promote tumorigenesis and metastasis #MMPMID27167110 Liu Q; Cheng Z; Luo L; Yang Y; Zhang Z; Ma H; Chen T; Huang X; Lin SY; Jin M; Li Q; Li X Oncotarget 2016[Jun]; 7 (24): 36800-13 PMID27167110show ga MUC16/CA125 has been identified as a prominent cancer biomarker, especially for epithelial ovarian cancers, in clinical test for over three decades. Due to its huge mass, limited knowledge of MUC16 was acquired previously. By utilizing a well characterized self-made MUC16 monoclonal antibody, we identified the endogenous interaction between a C-terminal fragment of MUC16 (MUC16C) and ?-catenin for the first time, and further elucidated that trans-activation domain of ?-catenin is required for this interaction. Such interaction could activate the Wnt/?-catenin signaling pathway by facilitating cytosol-nucleus transportation of ?-catenin, consequently induce cell proliferation and the migration, eventually lead to tumorigenesis and metastasis in nude mice. Consistently, knockdown of MUC16 significantly weakened the capabilities of cells for proliferation and migration. Based on our discovery, we suggest that MUC16 appears as an attractive target for the development of effective anticancer drugs. äC-terminus of MUC16 activates Wnt signaling pathway through its intera(epmc).pdf DeepDyve Pubget Overpricing