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10.18632/oncotarget.9269 http://scihub22266oqcxt.onion/10.18632/oncotarget.9269 C5095015!5095015 !27183908     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27183908 &cmd=llinks): Failed to open stream: HTTP request failed! 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ISL1, a novel regulator of CCNB1, CCNB2 and c-MYC genes, promotes gastric cancer cell proliferation and tumor growth |pdf=|usr=}}{{27183908 }} gab.com Text ISL1, a novel regulator of CCNB1, CCNB2 and c-MYC genes, promotes gastric cancer cell proliferation and tumor growth JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27183908 #FOAvip Islet-1 (ISL1) belongs to the LIM homeodomain transcription factor family, which is specifically expressed in certain tissue types only. Previously, we reported that ISL1 is aberrantly overexpressed in gastric cancer (GC). However, its role in GC is not clear. Here, we report that ISL1 is aberrantly upregulated not only in human gastric carcinoma tissues but also in some GC cell lines. Upregulated ISL1 expression enhanced xenografted gastric carcinoma development, while ISL1 knockdown inhibited GC growth in nude mice. ISL1 overexpression promoted GC cell proliferation, colony formation, and cell growth in soft agar, and facilitated cell cycle transition in GC cells, demonstrated an increase in the proportion of cells in the G2/M and S phases and a decrease in the proportion of cells in the G1 phase. Furthermore, we provide evidence that ISL1 is a novel regulator of the cyclin B1 (CCNB1), cyclin B2 (CCNB2) and c-myc (c-MYC) genes. ISL1 activated the expression of these genes in GC cells by binding to the conserved binding sites on their promoters or enhancers. The expression levels of the genes were decreased in response to ISL1 knockdown. Therefore, ISL1 may serve as a potential therapeutic target in GC. Twit Text FOAVip ISL1, a novel regulator of CCNB1, CCNB2 and c-MYC genes, promotes gastric cancer cell proliferation and tumor growth ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27183908 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27183908 #FOAvip English Wikipedia <ref>{{Cite pmid|27183908 }}</ref> ISL1, a novel regulator of CCNB1, CCNB2 and c-MYC genes, promotes gastric cancer cell proliferation and tumor growth #MMPMID27183908 Shi Q ; Wang W ; Jia Z ; Chen P ; Ma K ; Zhou C Oncotarget 2016[Jun]; 7 (24 ): 36489-36500 PMID27183908 show ga Islet-1 (ISL1) belongs to the LIM homeodomain transcription factor family, which is specifically expressed in certain tissue types only. Previously, we reported that ISL1 is aberrantly overexpressed in gastric cancer (GC). However, its role in GC is not clear. Here, we report that ISL1 is aberrantly upregulated not only in human gastric carcinoma tissues but also in some GC cell lines. Upregulated ISL1 expression enhanced xenografted gastric carcinoma development, while ISL1 knockdown inhibited GC growth in nude mice. ISL1 overexpression promoted GC cell proliferation, colony formation, and cell growth in soft agar, and facilitated cell cycle transition in GC cells, demonstrated an increase in the proportion of cells in the G2/M and S phases and a decrease in the proportion of cells in the G1 phase. Furthermore, we provide evidence that ISL1 is a novel regulator of the cyclin B1 (CCNB1), cyclin B2 (CCNB2) and c-myc (c-MYC) genes. ISL1 activated the expression of these genes in GC cells by binding to the conserved binding sites on their promoters or enhancers. The expression levels of the genes were decreased in response to ISL1 knockdown. Therefore, ISL1 may serve as a potential therapeutic target in GC. |Animals [MESH] |Base Sequence [MESH] |Cell Cycle/genetics [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/*genetics [MESH] |Cyclin B1/*genetics/metabolism [MESH] |Cyclin B2/*genetics/metabolism [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |LIM-Homeodomain Proteins/*genetics/metabolism [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Protein Binding [MESH] |Proto-Oncogene Proteins c-myc/*genetics/metabolism [MESH] |RNA Interference [MESH] |Regulatory Sequences, Nucleic Acid/genetics [MESH] |Stomach Neoplasms/*genetics/metabolism/pathology [MESH] |Transcription Factors/*genetics/metabolism [MESH]ISL1, a novel regulator of CCNB1, CCNB2 and c-MYC genes, promotes gast(epmc).pdf DeepDyve Pubget Overpricing