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10.18632/oncotarget.9199 http://scihub22266oqcxt.onion/10.18632/oncotarget.9199 C5094998!5094998 !27167112     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27167112 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (24 ): 36255-36265 Nephropedia Template TP {{tp|p=27167112 |t=2016. The Hippo transducer TAZ promotes cell proliferation and tumor formation of glioblastoma cells through EGFR pathway |pdf=|usr=}}{{27167112 }} gab.com Text The Hippo transducer TAZ promotes cell proliferation and tumor formation of glioblastoma cells through EGFR pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27167112 #FOAvip TAZ, a WW-domain-containing transcriptional co-activator, is important for development of various tissues in mammals. Recently, TAZ has been found to be overexpressed in some types of human cancers. However, the role of TAZ in glioblastoma remains unclear. In this study, we found that TAZ was overexpressed in prognostically poor glioblastoma patients. Through knocking down or overexpressing TAZ in U87 and LN229 cells, the expression level of TAZ was found to be positively related to cell proliferation in vitro and tumor formation in vivo. Further investigation indicated that TAZ could significantly promote the acceleration of cell cycle. Moreover, the western blot for p-EGFR, p-AKT, p-ERK1/2, p21, cyclin E and CDK2 proteins, target genes of the EGFR pathway, indicated that TAZ significantly activated EGFR/AKT/ERK signaling. Additionally, the blockage of EGFR pathway resulted in a significantly inhibition of cell proliferation induced by TAZ. Taken together, these results demonstrate that TAZ can promote proliferation and tumor formation in glioblastoma cells by potentiating the EGFR/AKT/ERK pathway, and provide the evidence for promising target for the treatment of glioblastoma. Twit Text FOAVip The Hippo transducer TAZ promotes cell proliferation and tumor formation of glioblastoma cells through EGFR pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27167112 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27167112 #FOAvip English Wikipedia <ref>{{Cite pmid|27167112 }}</ref> The Hippo transducer TAZ promotes cell proliferation and tumor formation of glioblastoma cells through EGFR pathway #MMPMID27167112 Yang R ; Wu Y ; Zou J ; Zhou J ; Wang M ; Hao X ; Cui H Oncotarget 2016[Jun]; 7 (24 ): 36255-36265 PMID27167112 show ga TAZ, a WW-domain-containing transcriptional co-activator, is important for development of various tissues in mammals. Recently, TAZ has been found to be overexpressed in some types of human cancers. However, the role of TAZ in glioblastoma remains unclear. In this study, we found that TAZ was overexpressed in prognostically poor glioblastoma patients. Through knocking down or overexpressing TAZ in U87 and LN229 cells, the expression level of TAZ was found to be positively related to cell proliferation in vitro and tumor formation in vivo. Further investigation indicated that TAZ could significantly promote the acceleration of cell cycle. Moreover, the western blot for p-EGFR, p-AKT, p-ERK1/2, p21, cyclin E and CDK2 proteins, target genes of the EGFR pathway, indicated that TAZ significantly activated EGFR/AKT/ERK signaling. Additionally, the blockage of EGFR pathway resulted in a significantly inhibition of cell proliferation induced by TAZ. Taken together, these results demonstrate that TAZ can promote proliferation and tumor formation in glioblastoma cells by potentiating the EGFR/AKT/ERK pathway, and provide the evidence for promising target for the treatment of glioblastoma. |*Cell Proliferation [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Blotting, Western [MESH] |Cell Cycle/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Survival/drug effects [MESH] |ErbB Receptors/antagonists & inhibitors/*metabolism [MESH] |Erlotinib Hydrochloride/pharmacology [MESH] |Glioblastoma/genetics/*metabolism/pathology [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/genetics/*metabolism [MESH] |Male [MESH] |Mice, Nude [MESH] |Protein Kinase Inhibitors/pharmacology [MESH] |RNA Interference [MESH] |Trans-Activators [MESH] |Transcription Factors [MESH] |Transcriptional Coactivator with PDZ-Binding Motif Proteins [MESH]The Hippo transducer TAZ promotes cell proliferation and tumor formati(epmc).pdf DeepDyve Pubget Overpricing