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10.18632/oncotarget.9543 http://scihub22266oqcxt.onion/10.18632/oncotarget.9543 C5094951!5094951 !27224922     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27224922 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (24 ): 35643-35654 Nephropedia Template TP {{tp|p=27224922 |t=2016. Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation |pdf=|usr=}}{{27224922 }} gab.com Text Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27224922 #FOAvip Neddylation, a newly identified post-translational modification, is significant for the activity and stability of target proteins. The exact role of neddylation in the pathogenesis of inflammatory bowel disease, specifically those mediated by dendritic cells (DCs), was still rarely reported. Here, we showed that inhibition of neddylation protected mice from mucosal inflammation. Targeting neddylation also inhibited DC maturation characterized by reduced cytokine production, down-regulated costimulatory molecules and suppressed capacity in allogeneic T cell stimulation. Additionally, inactivation of neddylation promotes caspase dependent apoptosis of DCs. These phenomena were attributed to the inactivation of mTOR, which was caused by Cullin-1 deneddylation induced Deptor accumulation. Together, our findings revealed that neddylation inhibition suppressed DC functions through mTOR signaling pathway and provided a potential therapeutic opportunity in inflammatory bowel diseases. Twit Text FOAVip Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27224922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27224922 #FOAvip English Wikipedia <ref>{{Cite pmid|27224922 }}</ref> Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation #MMPMID27224922 Cheng M ; Hu S ; Wang Z ; Pei Y ; Fan R ; Liu X ; Wang L ; Zhou J ; Zheng S ; Zhang T ; Lin Y ; Zhang M ; Tao R ; Zhong J Oncotarget 2016[Jun]; 7 (24 ): 35643-35654 PMID27224922 show ga Neddylation, a newly identified post-translational modification, is significant for the activity and stability of target proteins. The exact role of neddylation in the pathogenesis of inflammatory bowel disease, specifically those mediated by dendritic cells (DCs), was still rarely reported. Here, we showed that inhibition of neddylation protected mice from mucosal inflammation. Targeting neddylation also inhibited DC maturation characterized by reduced cytokine production, down-regulated costimulatory molecules and suppressed capacity in allogeneic T cell stimulation. Additionally, inactivation of neddylation promotes caspase dependent apoptosis of DCs. These phenomena were attributed to the inactivation of mTOR, which was caused by Cullin-1 deneddylation induced Deptor accumulation. Together, our findings revealed that neddylation inhibition suppressed DC functions through mTOR signaling pathway and provided a potential therapeutic opportunity in inflammatory bowel diseases. |Animals [MESH] |Apoptosis/physiology [MESH] |Caspase 3/metabolism [MESH] |Caspase 7/metabolism [MESH] |Cell Differentiation [MESH] |Cells, Cultured [MESH] |Cullin Proteins/*metabolism [MESH] |Cyclopentanes/pharmacology/therapeutic use [MESH] |Cytokines/metabolism [MESH] |Dendritic Cells/*physiology [MESH] |Disease Models, Animal [MESH] |Down-Regulation [MESH] |Enzyme Inhibitors/pharmacology/therapeutic use [MESH] |Humans [MESH] |Inflammatory Bowel Diseases/drug therapy/*immunology [MESH] |Intracellular Signaling Peptides and Proteins/*metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Protein Processing, Post-Translational/drug effects/*physiology [MESH] |Pyrimidines/pharmacology/therapeutic use [MESH] |Signal Transduction/drug effects [MESH]Inhibition of neddylation regulates dendritic cell functions via Depto(epmc).pdf DeepDyve Pubget Overpricing