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2016 ; 10
(11
): e0004749
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating
Procedures Used in the NIDIAG Febrile Syndrome Study
#MMPMID27812090
Alirol E
; Horie NS
; Barbé B
; Lejon V
; Verdonck K
; Gillet P
; Jacobs J
; Büscher P
; Kanal B
; Bhattarai NR
; El Safi S
; Phe T
; Lim K
; Leng L
; Lutumba P
; Mukendi D
; Bottieau E
; Boelaert M
; Rijal S
; Chappuis F
PLoS Negl Trop Dis
2016[Nov]; 10
(11
): e0004749
PMID27812090
show ga
In resource-limited settings, the scarcity of skilled personnel and adequate
laboratory facilities makes the differential diagnosis of fevers complex [1-5].
Febrile illnesses are diagnosed clinically in most rural centers, and both Rapid
Diagnostic Tests (RDTs) and clinical algorithms can be valuable aids to health
workers and facilitate therapeutic decisions [6,7]. The persistent fever syndrome
targeted by NIDIAG is defined as presence of fever for at least one week. The
NIDIAG clinical research consortium focused on potentially severe and treatable
infections and therefore targeted the following conditions as differential
diagnosis of persistent fever: visceral leishmaniasis (VL), human African
trypanosomiasis (HAT), enteric (typhoid and paratyphoid) fever, brucellosis,
melioidosis, leptospirosis, malaria, tuberculosis, amoebic liver abscess,
relapsing fever, HIV/AIDS, rickettsiosis, and other infectious diseases (e.g.,
pneumonia). From January 2013 to October 2014, a prospective clinical phase III
diagnostic accuracy study was conducted in one site in Cambodia, two sites in
Nepal, two sites in Democratic Republic of the Congo (DRC), and one site in Sudan
(clinicaltrials.gov no. NCT01766830). The study objectives were to (1) determine
the prevalence of the target diseases in patients presenting with persistent
fever, (2) assess the predictive value of clinical and first-line laboratory
features, and (3) assess the diagnostic accuracy of several RDTs for the
diagnosis of the different target conditions.