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10.1371/journal.pone.0165750 http://scihub22266oqcxt.onion/10.1371/journal.pone.0165750 C5094682!5094682 !27812149     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27812149 &cmd=llinks): Failed to open stream: HTTP request failed! 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Renal Outcomes of Pioglitazone Compared with Acarbose in Diabetic Patients: A Randomized Controlled Study |pdf=|usr=}}{{27812149 }} gab.com Text Renal Outcomes of Pioglitazone Compared with Acarbose in Diabetic Patients: A Randomized Controlled Study JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27812149 #FOAvip OBJECTIVE: To assess the effect of pioglitazone on renal outcome, including urinary albumin excretion and estimated glomerular filtration rate (eGFR), in diabetic patients. DESIGN: A prospective, randomized, open-labeled, controlled study. SETTING: Taipei Veterans General Hospital. PATIENTS: Sixty type 2 diabetic patients treated with sulfonylureas and metformin, whose glycated hemoglobin (HbA1c) levels were between 7% and 10% and eGFR was between 45 and 125 mL/min/1.73 m2. INTERVENTION: The patients were randomized to receive acarbose or pioglitazone and followed up for 6 months. Thirty patients were randomly assigned to receive acarbose, and 30 patients were assigned to receive pioglitazone. MEASUREMENTS: The primary study endpoint was the changes in the urinary albumin-to-creatinine ratio (UACR). The secondary endpoint was the changes in eGFR and other parameters. RESULTS: After 6 months of treatment, the mean changes in UACR were -18 ± 104 and 12 ± 85 (p = 0.25, between groups) for the acarbose and pioglitazone groups, respectively. The mean changes in eGFR were 0 ± 14 and -7 ± 16 mL/min/1.73 m2 (p = 0.09, between groups) for the acarbose and pioglitazone groups, respectively. The reductions in HbA1c were similar in both groups. Fasting blood glucose was lower in the pioglitazone group than in the acarbose group. Significant body weight gain was observed in the pioglitazone group as compared with the acarbose group (1.3 ± 2.8 vs. -0.6 ± 1.5 kg, p = 0.002). CONCLUSION: In type 2 diabetic patients who were treated with sulfonylureas and metformin and possessed HbA1c levels between 7% and 10%, additional acarbose or pioglitazone for 6 months provided similar glycemic control and eGFR and UACR changes. In the pioglitazone group, the patients exhibited significant body weight gain. TRIAL REGISTRATION: ClinicalTrials.gov NCT01175486. Twit Text FOAVip Renal Outcomes of Pioglitazone Compared with Acarbose in Diabetic Patients: A Randomized Controlled Study ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27812149 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27812149 #FOAvip English Wikipedia <ref>{{Cite pmid|27812149 }}</ref> Renal Outcomes of Pioglitazone Compared with Acarbose in Diabetic Patients: A Randomized Controlled Study #MMPMID27812149 Chen YH ; Tarng DC ; Chen HS PLoS One 2016[]; 11 (11 ): e0165750 PMID27812149 show ga OBJECTIVE: To assess the effect of pioglitazone on renal outcome, including urinary albumin excretion and estimated glomerular filtration rate (eGFR), in diabetic patients. DESIGN: A prospective, randomized, open-labeled, controlled study. SETTING: Taipei Veterans General Hospital. PATIENTS: Sixty type 2 diabetic patients treated with sulfonylureas and metformin, whose glycated hemoglobin (HbA1c) levels were between 7% and 10% and eGFR was between 45 and 125 mL/min/1.73 m2. INTERVENTION: The patients were randomized to receive acarbose or pioglitazone and followed up for 6 months. Thirty patients were randomly assigned to receive acarbose, and 30 patients were assigned to receive pioglitazone. MEASUREMENTS: The primary study endpoint was the changes in the urinary albumin-to-creatinine ratio (UACR). The secondary endpoint was the changes in eGFR and other parameters. RESULTS: After 6 months of treatment, the mean changes in UACR were -18 ± 104 and 12 ± 85 (p = 0.25, between groups) for the acarbose and pioglitazone groups, respectively. The mean changes in eGFR were 0 ± 14 and -7 ± 16 mL/min/1.73 m2 (p = 0.09, between groups) for the acarbose and pioglitazone groups, respectively. The reductions in HbA1c were similar in both groups. Fasting blood glucose was lower in the pioglitazone group than in the acarbose group. Significant body weight gain was observed in the pioglitazone group as compared with the acarbose group (1.3 ± 2.8 vs. -0.6 ± 1.5 kg, p = 0.002). CONCLUSION: In type 2 diabetic patients who were treated with sulfonylureas and metformin and possessed HbA1c levels between 7% and 10%, additional acarbose or pioglitazone for 6 months provided similar glycemic control and eGFR and UACR changes. In the pioglitazone group, the patients exhibited significant body weight gain. TRIAL REGISTRATION: ClinicalTrials.gov NCT01175486. |Acarbose/*therapeutic use [MESH] |Aged [MESH] |Albumins/metabolism [MESH] |Albuminuria [MESH] |Blood Glucose/*drug effects [MESH] |Creatinine/urine [MESH] |Diabetes Mellitus, Type 2/*blood/*drug therapy [MESH] |Drug Therapy, Combination/methods [MESH] |Female [MESH] |Glomerular Filtration Rate/drug effects [MESH] |Glycated Hemoglobin/*drug effects [MESH] |Glycoside Hydrolase Inhibitors/*therapeutic use [MESH] |Humans [MESH] |Hypoglycemic Agents/*therapeutic use [MESH] |Kidney Failure, Chronic/prevention & control [MESH] |Male [MESH] |Metformin/therapeutic use [MESH] |Pioglitazone [MESH] |Prospective Studies [MESH] |Sulfonylurea Compounds/therapeutic use [MESH] |Thiazolidinediones/*therapeutic use [MESH]Renal Outcomes of Pioglitazone Compared with Acarbose in Diabetic Pati(epmc).pdf DeepDyve Pubget Overpricing