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10.1111/apt.13546

http://scihub22266oqcxt.onion/10.1111/apt.13546
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suck abstract from ncbi


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pmid26849527      Aliment+Pharmacol+Ther 2016 ; 43 (6): 725-33
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  • Clostridium difficile Associated Risk of Death Score (CARDS): A novel severity score to predict mortality among hospitalized patients with Clostridium difficile infection #MMPMID26849527
  • Kassam Z; Fabersunne CC; Smith MB; Alm EJ; Kaplan GG; Nguyen GC; Ananthakrishnan AN
  • Aliment Pharmacol Ther 2016[Mar]; 43 (6): 725-33 PMID26849527show ga
  • Background: Clostridium difficile infection (CDI) is public health threat and associated with significant mortality. However, there is a paucity of objectively derived CDI severity scoring systems to predict mortality. Aims: To develop a novel CDI risk score to predict mortality entitled: Clostridium difficileAssociated Risk of Death Score (CARDS). Methods: We obtained data from the United States 2011 Nationwide Inpatient Sample (NIS) database. All CDI-associated hospitalizations were identified using discharge codes (ICD-9-CM, 008.45). Multivariate logistic regression was utilized to identify independent predictors of mortality. CARDS was calculated by assigning a numeric weight to each parameter based on their odds ratio in the final logistic model. Predictive properties of model discrimination were assessed using the c-statistic and validated in an independent sample using the 2010 NIS database. Results: We identified 77,776 hospitalizations, yielding an estimate of 374,747 cases with an associated diagnosis of CDI in the United States, 8% of whom died in the hospital. The 8 severity score predictors were identified on multivariate analysis: age, cardiopulmonary disease, malignancy, diabetes, inflammatory bowel disease, acute renal failure, liver disease and ICU admission, with weights ranging from ?1 (for diabetes) to 5 (for ICU admission). The overall risk score in the cohort ranged from 0 to 18. Mortality increased significantly as CARDS increased. CDI-associated mortality was 1.2% with a CARDS of 0 compared to 100% with CARDS of 18. The model performed equally well in our validation cohort. Conclusion: CARDS is a promising simple severity score to predict mortality among those hospitalized with CDI.
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