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2016 ; 7
(ä): 464
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Killing of Microbes and Cancer by the Immune System with Three Mammalian
Pore-Forming Killer Proteins
#MMPMID27857713
Podack ER
; Munson GP
Front Immunol
2016[]; 7
(ä): 464
PMID27857713
show ga
Immunology is the science of biological warfare between the defenses of our
immune systems and offensive pathogenic microbes and cancers. Over the course of
his scientific career, Eckhard R. Podack made several seminal discoveries that
elucidated key aspects of this warfare at a molecular level. When Eckhard joined
the complement laboratory of Müller-Eberhard in 1974, he was fascinated by two
questions: (1) what is the molecular mechanism by which complement kills invasive
bacteria? and (2) which one of the complement components is the killer molecule?
Eckhard's quest to answer these questions would lead to the discovery C9 and
later, two additional pore-forming killer molecules of the immune system. Here is
a brief account of how he discovered poly-C9, the pore-forming protein of
complement in blood and interstitial fluids: Perforin-1, expressed by natural
killer cells and cytotoxic T lymphocytes; and Perforin-2 (MPEG1), expressed by
all cell types examined to date. All the three killing systems are crucial for
our survival and health.