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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Rep 2016 ; 17 (2): 387-98 Nephropedia Template TP
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Self-antigen-driven thymic B cell class switching promotes T cell central tolerance #MMPMID27705788
Perera J; Zheng Z; Li S; Gudjonson H; Kalinina O; Benichou JIC; Block KE; Louzoun Y; Yin D; Chong AS; Dinner AR; Weigert M; Huang H
Cell Rep 2016[Oct]; 17 (2): 387-98 PMID27705788show ga
B cells are unique antigen presenting cells because their antigen presentation machinery is closely tied to the B cell receptor. Autoreactive thymic B cells can efficiently present cognate self-antigens to mediate CD4+ T cell negative selection. However, the nature of thymocyte-thymic B cell interaction, and how this interaction affects the selection of thymic B cell repertoire and in turn the T cell repertoire are not well understood. Here we demonstrate that a large percentage of thymic B cells have undergone class switching intrathymically. Thymic B cell class switching requires cognate interaction with specific T cells. Class-switched thymic B cells have a distinct repertoire when compared to unswitched thymic B cells or splenic B cells. Particularly, autoreactive B cell specificities preferentially expand in the thymus by undergoing class switching, and these enriched, class-switched autoreactive thymic B cells play important role in CD4 T cell tolerance.