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10.1158/0008-5472.CAN-16-1547 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-16-1547 C5091083!5091083!27496710     free     free     free       Cancer+Res 2016 ; 76 (18): 5573-83 Nephropedia Template TP {{tp|p=27496710|t=2016. Nestin Mediates Hedgehog Pathway Tumorigenesis |pdf=|usr=}}{{27496710}} gab.com Text Nestin Mediates Hedgehog Pathway Tumorigenesis JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27496710 #FOAvip The intermediate filament protein Nestin serves as a biomarker for stem cells and has been used to identify subsets of cancer stem-like cells. However, the mechanistic contributions of Nestin to cancer pathogenesis are not understood. Here we report that Nestin binds the hedgehog pathway transcription factor Gli3 to mediate the development of medulloblastomas of the hedgehog subtype. In a mouse model system, Nestin levels increased progressively during medulloblastoma formation resulting in enhanced tumor growth. Conversely, loss of Nestin dramatically inhibited proliferation and promoted differentiation. Mechanistic investigations revealed that the tumor-promoting effects of Nestin were mediated by binding to Gli3, a zinc finger transcription factor that negatively regulates hedgehog signaling. Nestin binding to Gli3 blocked Gli3 phosphorylation and its subsequent proteolytic processing, thereby abrogating its ability to negatively regulate the hedgehog pathway. Our findings show how Nestin drives hedgehog pathway-driven cancers and uncover in Gli3 a therapeutic target to treat these malignancies. Twit Text FOAVip Nestin Mediates Hedgehog Pathway Tumorigenesis ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27496710 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27496710 #FOAvip English Wikipedia <ref>{{Cite pmid|27496710}}</ref> Nestin Mediates Hedgehog Pathway Tumorigenesis #MMPMID27496710 Li P; Lee E; Du F; Gordon RE; Yuelling LW; Liu Y; Ng JM; Zhang H; Wu J; Korshunov A; Pfister S; Curran T; Yang Zj Cancer Res 2016[Sep]; 76 (18): 5573-83 PMID27496710show ga The intermediate filament protein Nestin serves as a biomarker for stem cells and has been used to identify subsets of cancer stem-like cells. However, the mechanistic contributions of Nestin to cancer pathogenesis are not understood. Here we report that Nestin binds the hedgehog pathway transcription factor Gli3 to mediate the development of medulloblastomas of the hedgehog subtype. In a mouse model system, Nestin levels increased progressively during medulloblastoma formation resulting in enhanced tumor growth. Conversely, loss of Nestin dramatically inhibited proliferation and promoted differentiation. Mechanistic investigations revealed that the tumor-promoting effects of Nestin were mediated by binding to Gli3, a zinc finger transcription factor that negatively regulates hedgehog signaling. Nestin binding to Gli3 blocked Gli3 phosphorylation and its subsequent proteolytic processing, thereby abrogating its ability to negatively regulate the hedgehog pathway. Our findings show how Nestin drives hedgehog pathway-driven cancers and uncover in Gli3 a therapeutic target to treat these malignancies. äNestin Mediates Hedgehog Pathway Tumorigenesis (epmc).pdf DeepDyve Pubget Overpricing