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2016 ; 48
(11
): 1817-1821
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Renal functional outcomes after robotic multiplex partial nephrectomy: the
National Cancer Institute experience with robotic partial nephrectomy for 3 or
more tumors in a single kidney
#MMPMID27515314
Hankins RA
; Walton-Diaz A
; Truong H
; Shih J
; Bratslavsky G
; Pinto PA
; Marston Linehan W
; Metwalli AR
Int Urol Nephrol
2016[Nov]; 48
(11
): 1817-1821
PMID27515314
show ga
OBJECTIVE: To identify renal function outcomes after robotic multiplex partial
nephrectomy (RMxPNx), we reviewed our institutional database at the National
Institutes of Health, National Cancer Institute. To our knowledge, we present the
largest series of RMxPNx renal function outcomes to date. Robotic partial
nephrectomy has been employed for oncologic control and to prevent dialysis
dependence in hereditary multifocal renal cell carcinoma conditions. We have
termed robotic surgery on a single kidney with three or more lesions a RMxPNx.
MATERIALS AND METHODS: We evaluated patients from a prospectively maintained
database at a single institution (NIH/NCI) that underwent RMxPNx from 2007 to
2013. Demographic and operative data were compiled with statistical analysis with
T test performed to determine renal function outcomes. RESULTS: A total of 54
patients underwent RMxPNx. Mean number of tumors removed was 8.63 (range 3-52).
Mean preoperative creatinine and eGFR were 1.02 ± 0.26 mg/dL and
85.4 ± 21.5 mL/min, respectively. Postoperatively, creatinine increased from
baseline by 0.45 mg/dL (p < 0.001). Similarly, a mean decrease in eGFR by
24.6 mL/min was observed (p < 0.001). At 3-month follow-up, the creatinine
increase from baseline was 0.05 mg/dL (p = 0.10) and mean decrease in eGFR was
3.01 mL/min (p = 0.21). When stratifying based on preoperative CKD stages I-III,
similar results were observed. CONCLUSION: Robotic multiplex partial nephrectomy
is a safe and feasible approach to patients with multifocal renal masses. These
complex surgeries have a demonstrated learning curve, but this minimally invasive
approach for nephron-sparing surgery allows patients to preserve renal function
where they would otherwise require open surgery or a radical nephrectomy.