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10.1098/rsob.160119 http://scihub22266oqcxt.onion/10.1098/rsob.160119 C5090056!5090056!27805903     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27805903&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Open+Biol 2016 ; 6 (10): ä Nephropedia Template TP {{tp|p=27805903|t=2016. Disease implication of hyper-Hippo signalling |pdf=|usr=}}{{27805903}} gab.com Text Disease implication of hyper-Hippo signalling JO: Open Biol http://www.kidney.de/pget.php?&tw=1&pmid=27805903 #FOAvip The Hippo signalling pathway regulates cellular proliferation, apoptosis and differentiation, thus exerting profound effects on cellular homeostasis. Inhibition of Hippo signalling has been frequently implicated in human cancers, indicating a well-known tumour suppressor function of the Hippo pathway. However, it is less certain whether and how hyperactivation of the Hippo pathway affects biological outcome in living cells. This review describes current knowledge of the regulatory mechanisms of the Hippo pathway, mainly focusing on hyperactivation of the Hippo signalling nexus. The disease implications of hyperactivated Hippo signalling have also been discussed, including arrhythmogenic cardiomyopathy, Sveinsson's chorioretinal atrophy, Alzheimer's disease, amyotrophic lateral sclerosis and diabetes. By highlighting the significance of disease-relevant Hippo signalling activation, this review can offer exciting prospects to address the onset and potential reversal of Hippo-related disorders. Twit Text FOAVip Disease implication of hyper-Hippo signalling ????Open Biol http://www.kidney.de/pget.php?&tw=1&pmid=27805903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27805903 #FOAvip English Wikipedia <ref>{{Cite pmid|27805903}}</ref> Disease implication of hyper-Hippo signalling #MMPMID27805903 Wang SP; Wang LH Open Biol 2016[Oct]; 6 (10): ä PMID27805903show ga The Hippo signalling pathway regulates cellular proliferation, apoptosis and differentiation, thus exerting profound effects on cellular homeostasis. Inhibition of Hippo signalling has been frequently implicated in human cancers, indicating a well-known tumour suppressor function of the Hippo pathway. However, it is less certain whether and how hyperactivation of the Hippo pathway affects biological outcome in living cells. This review describes current knowledge of the regulatory mechanisms of the Hippo pathway, mainly focusing on hyperactivation of the Hippo signalling nexus. The disease implications of hyperactivated Hippo signalling have also been discussed, including arrhythmogenic cardiomyopathy, Sveinsson's chorioretinal atrophy, Alzheimer's disease, amyotrophic lateral sclerosis and diabetes. By highlighting the significance of disease-relevant Hippo signalling activation, this review can offer exciting prospects to address the onset and potential reversal of Hippo-related disorders. äDisease implication of hyper-Hippo signalling (epmc).pdf DeepDyve Pubget Overpricing