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10.1159/000446825 http://scihub22266oqcxt.onion/10.1159/000446825 C5089923!5089923!27336915     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Innate+Immun 2016 ; 8 (6): 550-63 Nephropedia Template TP {{tp|p=27336915|t=2016. Cystic Fibrosis Lung Immunity: The Role of the Macrophage |pdf=|usr=}}{{27336915}} gab.com Text Cystic Fibrosis Lung Immunity: The Role of the Macrophage JO: J Innate Immun http://www.kidney.de/pget.php?&tw=1&pmid=27336915 #FOAvip Cystic fibrosis (CF) pathophysiology is hallmarked by excessive inflammation and the inability to efficiently resolve lung infections, contributing to major morbidity and eventually the mortality of patients with this disease. Macrophages (M?s) are major players in lung homeostasis through their diverse contributions to both the innate and adaptive immune networks. The setting of M? function and activity in CF is multifaceted, encompassing the response to the unique environmental cues in the CF lung as well as the intrinsic changes resulting from CFTR dysfunction. The complexity is further enhanced with the identification of modifier genes, which modulate the CFTR contribution to disease, resulting in epigenetic and transcriptional shifts in M? phenotype. This review focuses on the contribution of M? to lung homeostasis, providing an overview of the diverse literature and various perspectives on the role of these immune guardians in CF. Twit Text FOAVip Cystic Fibrosis Lung Immunity: The Role of the Macrophage ????J Innate Immun http://www.kidney.de/pget.php?&tw=1&pmid=27336915 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27336915 #FOAvip English Wikipedia <ref>{{Cite pmid|27336915}}</ref> Cystic Fibrosis Lung Immunity: The Role of the Macrophage #MMPMID27336915 Bruscia EM; Bonfield TL J Innate Immun 2016[Nov]; 8 (6): 550-63 PMID27336915show ga Cystic fibrosis (CF) pathophysiology is hallmarked by excessive inflammation and the inability to efficiently resolve lung infections, contributing to major morbidity and eventually the mortality of patients with this disease. Macrophages (M?s) are major players in lung homeostasis through their diverse contributions to both the innate and adaptive immune networks. The setting of M? function and activity in CF is multifaceted, encompassing the response to the unique environmental cues in the CF lung as well as the intrinsic changes resulting from CFTR dysfunction. The complexity is further enhanced with the identification of modifier genes, which modulate the CFTR contribution to disease, resulting in epigenetic and transcriptional shifts in M? phenotype. This review focuses on the contribution of M? to lung homeostasis, providing an overview of the diverse literature and various perspectives on the role of these immune guardians in CF. äCystic Fibrosis Lung Immunity: The Role of the Macrophage (epmc).pdf DeepDyve Pubget Overpricing