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10.7554/eLife.19027 http://scihub22266oqcxt.onion/10.7554/eLife.19027 C5089864!5089864!27690225     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2016 ; 5 (ä): ä Nephropedia Template TP {{tp|p=27690225|t=2016. Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network |pdf=|usr=}}{{27690225}} gab.com Text Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=27690225 #FOAvip The evolutionary mechanisms leading to duplicate gene retention are well understood, but the long-term impacts of paralog differentiation on the regulation of metabolism remain underappreciated. Here we experimentally dissect the functions of two pairs of ancient paralogs of the GALactose sugar utilization network in two yeast species. We show that the Saccharomyces uvarum network is more active, even as over-induction is prevented by a second co-repressor that the model yeast Saccharomyces cerevisiae lacks. Surprisingly, removal of this repression system leads to a strong growth arrest, likely due to overly rapid galactose catabolism and metabolic overload. Alternative sugars, such as fructose, circumvent metabolic control systems and exacerbate this phenotype. We further show that S. cerevisiae experiences homologous metabolic constraints that are subtler due to how the paralogs have diversified. These results show how the functional differentiation of paralogs continues to shape regulatory network architectures and metabolic strategies long after initial preservation.DOI:http://dx.doi.org/10.7554/eLife.19027.001 Twit Text FOAVip Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=27690225 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27690225 #FOAvip English Wikipedia <ref>{{Cite pmid|27690225}}</ref> Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network #MMPMID27690225 Kuang MC; Hutchins PD; Russell JD; Coon JJ; Hittinger CT eLife 2016[]; 5 (ä): ä PMID27690225show ga The evolutionary mechanisms leading to duplicate gene retention are well understood, but the long-term impacts of paralog differentiation on the regulation of metabolism remain underappreciated. Here we experimentally dissect the functions of two pairs of ancient paralogs of the GALactose sugar utilization network in two yeast species. We show that the Saccharomyces uvarum network is more active, even as over-induction is prevented by a second co-repressor that the model yeast Saccharomyces cerevisiae lacks. Surprisingly, removal of this repression system leads to a strong growth arrest, likely due to overly rapid galactose catabolism and metabolic overload. Alternative sugars, such as fructose, circumvent metabolic control systems and exacerbate this phenotype. We further show that S. cerevisiae experiences homologous metabolic constraints that are subtler due to how the paralogs have diversified. These results show how the functional differentiation of paralogs continues to shape regulatory network architectures and metabolic strategies long after initial preservation.DOI:http://dx.doi.org/10.7554/eLife.19027.001 äOngoing resolution of duplicate gene functions shapes the diversificat(epmc).pdf DeepDyve Pubget Overpricing