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pmid24971780      Minerva+Ginecol 2014 ; 66 (3): 243-9
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  • TH17- and IL-17- mediated autoantibodies and placental oxidative stress play a role in the pathophysiology of pre-eclampsia #MMPMID24971780
  • CORNELIUS DC; LAMARCA B
  • Minerva Ginecol 2014[Jun]; 66 (3): 243-9 PMID24971780show ga
  • Pre-eclampsia is a multisystem disorder of pregnancy that affects 5?8% of pregnancies. The pathophysiologic mechanisms that lead to the development of pre-eclampsia are poorly understood. Higher than normal levels of circulating TH17 is observed in preeclamptic women compared to women with normal pregnancy. TH17 cells are a subset of CD4+ T helper cells that are characterized by their secretion of IL-17. Recent studies suggest a role for TH17 cells and IL-17 in the pathophysiology of pre-eclampsia. In this review, we will discuss the known function of TH17 cells and IL-17 in immunity and vascular function. We will then review the role of IL-17 and TH17 cells in normal pregnancy and their association with pre-eclampsia, followed by a discussion of the literature to examine a potential role for IL-17 and TH17 cells in mediating pathophysiology in pre-eclampsia.
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