Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1167/iovs.16-20162 http://scihub22266oqcxt.onion/10.1167/iovs.16-20162 C5089212!5089212!27787561     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Invest+Ophthalmol+Vis+Sci 2016 ; 57 (13): 5736-47 Nephropedia Template TP {{tp|p=27787561|t=2016. ?-Catenin/CBP?Dependent Signaling Regulates TGF-??Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells |pdf=|usr=}}{{27787561}} gab.com Text -Catenin/CBP Dependent Signaling Regulates TGF- Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells JO: Invest Ophthalmol Vis Sci http://www.kidney.de/pget.php?&tw=1&pmid=27787561 #FOAvip Purpose: Transforming growth factor-??induced epithelial?mesenchymal transition (EMT) is one of the main causes of posterior capsular opacification (PCO) or secondary cataract; however, the signaling events involved in TGF-??induced PCO have not been fully characterized. Here, we focus on examining the role of ?-catenin/cyclic AMP response element?binding protein (CREB)-binding protein (CBP) and ?-catenin/T-cell factor (TCF)-dependent signaling in regulating cytoskeletal dynamics during TGF-??induced EMT in lens epithelial explants. Methods: Rat lens epithelial explants were cultured in medium M199 in the absence of serum. Explants were treated with TGF-?2 in the presence or absence of the ?-catenin/CBP interaction inhibitor, ICG-001, or the ?-catenin/TCF interaction inhibitor, PNU-74654. Western blot and immunofluorescence experiments were carried out and analyzed. Results: An increase in the expression of fascin, an actin-bundling protein, was observed in the lens explants upon stimulation with TGF-?, and colocalized with F-actin filaments. Inhibition of ?-catenin/CBP interactions, but not ?-catenin/TCF interactions, led to a decrease in TGF-??induced fascin and stress fiber formation, as well as a decrease in the expression of known markers of EMT, ?-smooth muscle actin (?-SMA) and matrix metalloproteinase 9 (MMP9). In addition, inhibition of ?-catenin/CBP?dependent signaling also prevented TGF-??induced downregulation of epithelial cadherin (E-cadherin) in lens explants. Conclusions: We show that ?-catenin/CBP?dependent signaling regulates fascin, MMP9, and ?-SMA expression during TGF-??induced EMT. We demonstrate that ?-catenin/CBP?dependent signaling is crucial for TGF-??induced EMT in the lens. Twit Text FOAVip -Catenin/CBP Dependent Signaling Regulates TGF- Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells ????Invest Ophthalmol Vis Sci http://www.kidney.de/pget.php?&tw=1&pmid=27787561 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27787561 #FOAvip English Wikipedia <ref>{{Cite pmid|27787561}}</ref> ?-Catenin/CBP?Dependent Signaling Regulates TGF-??Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells #MMPMID27787561 Taiyab A; Korol A; Deschamps PA; West-Mays JA Invest Ophthalmol Vis Sci 2016[Oct]; 57 (13): 5736-47 PMID27787561show ga Purpose: Transforming growth factor-??induced epithelial?mesenchymal transition (EMT) is one of the main causes of posterior capsular opacification (PCO) or secondary cataract; however, the signaling events involved in TGF-??induced PCO have not been fully characterized. Here, we focus on examining the role of ?-catenin/cyclic AMP response element?binding protein (CREB)-binding protein (CBP) and ?-catenin/T-cell factor (TCF)-dependent signaling in regulating cytoskeletal dynamics during TGF-??induced EMT in lens epithelial explants. Methods: Rat lens epithelial explants were cultured in medium M199 in the absence of serum. Explants were treated with TGF-?2 in the presence or absence of the ?-catenin/CBP interaction inhibitor, ICG-001, or the ?-catenin/TCF interaction inhibitor, PNU-74654. Western blot and immunofluorescence experiments were carried out and analyzed. Results: An increase in the expression of fascin, an actin-bundling protein, was observed in the lens explants upon stimulation with TGF-?, and colocalized with F-actin filaments. Inhibition of ?-catenin/CBP interactions, but not ?-catenin/TCF interactions, led to a decrease in TGF-??induced fascin and stress fiber formation, as well as a decrease in the expression of known markers of EMT, ?-smooth muscle actin (?-SMA) and matrix metalloproteinase 9 (MMP9). In addition, inhibition of ?-catenin/CBP?dependent signaling also prevented TGF-??induced downregulation of epithelial cadherin (E-cadherin) in lens explants. Conclusions: We show that ?-catenin/CBP?dependent signaling regulates fascin, MMP9, and ?-SMA expression during TGF-??induced EMT. We demonstrate that ?-catenin/CBP?dependent signaling is crucial for TGF-??induced EMT in the lens. ä?-Catenin/CBP?Dependent Signaling Regulates TGF-??Induced Epithelial t(epmc).pdf DeepDyve Pubget Overpricing