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10.1167/iovs.16-20162 http://scihub22266oqcxt.onion/10.1167/iovs.16-20162 C5089212!5089212 !27787561     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27787561 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27787561 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Invest+Ophthalmol+Vis+Sci 2016 ; 57 (13 ): 5736-5747 Nephropedia Template TP {{tp|p=27787561 |t=2016. ?-Catenin/CBP-Dependent Signaling Regulates TGF-?-Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells |pdf=|usr=}}{{27787561 }} gab.com Text -Catenin/CBP-Dependent Signaling Regulates TGF- -Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells JO: Invest Ophthalmol Vis Sci http://www.kidney.de/pget.php?&tw=1&pmid=27787561 #FOAvip PURPOSE: Transforming growth factor-?-induced epithelial-mesenchymal transition (EMT) is one of the main causes of posterior capsular opacification (PCO) or secondary cataract; however, the signaling events involved in TGF-?-induced PCO have not been fully characterized. Here, we focus on examining the role of ?-catenin/cyclic AMP response element-binding protein (CREB)-binding protein (CBP) and ?-catenin/T-cell factor (TCF)-dependent signaling in regulating cytoskeletal dynamics during TGF-?-induced EMT in lens epithelial explants. METHODS: Rat lens epithelial explants were cultured in medium M199 in the absence of serum. Explants were treated with TGF-?2 in the presence or absence of the ?-catenin/CBP interaction inhibitor, ICG-001, or the ?-catenin/TCF interaction inhibitor, PNU-74654. Western blot and immunofluorescence experiments were carried out and analyzed. RESULTS: An increase in the expression of fascin, an actin-bundling protein, was observed in the lens explants upon stimulation with TGF-?, and colocalized with F-actin filaments. Inhibition of ?-catenin/CBP interactions, but not ?-catenin/TCF interactions, led to a decrease in TGF-?-induced fascin and stress fiber formation, as well as a decrease in the expression of known markers of EMT, ?-smooth muscle actin (?-SMA) and matrix metalloproteinase 9 (MMP9). In addition, inhibition of ?-catenin/CBP-dependent signaling also prevented TGF-?-induced downregulation of epithelial cadherin (E-cadherin) in lens explants. CONCLUSIONS: We show that ?-catenin/CBP-dependent signaling regulates fascin, MMP9, and ?-SMA expression during TGF-?-induced EMT. We demonstrate that ?-catenin/CBP-dependent signaling is crucial for TGF-?-induced EMT in the lens. Twit Text FOAVip -Catenin/CBP-Dependent Signaling Regulates TGF- -Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells ????Invest Ophthalmol Vis Sci http://www.kidney.de/pget.php?&tw=1&pmid=27787561 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27787561 #FOAvip English Wikipedia <ref>{{Cite pmid|27787561 }}</ref> ?-Catenin/CBP-Dependent Signaling Regulates TGF-?-Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells #MMPMID27787561 Taiyab A ; Korol A ; Deschamps PA ; West-Mays JA Invest Ophthalmol Vis Sci 2016[Oct]; 57 (13 ): 5736-5747 PMID27787561 show ga PURPOSE: Transforming growth factor-?-induced epithelial-mesenchymal transition (EMT) is one of the main causes of posterior capsular opacification (PCO) or secondary cataract; however, the signaling events involved in TGF-?-induced PCO have not been fully characterized. Here, we focus on examining the role of ?-catenin/cyclic AMP response element-binding protein (CREB)-binding protein (CBP) and ?-catenin/T-cell factor (TCF)-dependent signaling in regulating cytoskeletal dynamics during TGF-?-induced EMT in lens epithelial explants. METHODS: Rat lens epithelial explants were cultured in medium M199 in the absence of serum. Explants were treated with TGF-?2 in the presence or absence of the ?-catenin/CBP interaction inhibitor, ICG-001, or the ?-catenin/TCF interaction inhibitor, PNU-74654. Western blot and immunofluorescence experiments were carried out and analyzed. RESULTS: An increase in the expression of fascin, an actin-bundling protein, was observed in the lens explants upon stimulation with TGF-?, and colocalized with F-actin filaments. Inhibition of ?-catenin/CBP interactions, but not ?-catenin/TCF interactions, led to a decrease in TGF-?-induced fascin and stress fiber formation, as well as a decrease in the expression of known markers of EMT, ?-smooth muscle actin (?-SMA) and matrix metalloproteinase 9 (MMP9). In addition, inhibition of ?-catenin/CBP-dependent signaling also prevented TGF-?-induced downregulation of epithelial cadherin (E-cadherin) in lens explants. CONCLUSIONS: We show that ?-catenin/CBP-dependent signaling regulates fascin, MMP9, and ?-SMA expression during TGF-?-induced EMT. We demonstrate that ?-catenin/CBP-dependent signaling is crucial for TGF-?-induced EMT in the lens. |Actins [MESH] |Animals [MESH] |Blotting, Western [MESH] |Capsule Opacification/*metabolism/pathology [MESH] |Carrier Proteins/biosynthesis/drug effects [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Humans [MESH] |Microfilament Proteins/biosynthesis/drug effects [MESH] |Rats [MESH] |Rats, Wistar [MESH] |Recombinant Proteins [MESH] |Signal Transduction [MESH] |Transforming Growth Factor beta2/*pharmacology [MESH]?-Catenin/CBP-Dependent Signaling Regulates TGF-?-Induced Epithelial t(epmc).pdf DeepDyve Pubget Overpricing