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10.1016/j.celrep.2015.08.034 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.08.034 C5089067!5089067!26365182     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2015 ; 12 (11): 1842-52 Nephropedia Template TP {{tp|p=26365182|t=2015. Off target V(D)J recombination drives lymphomagenesis and is escalated by loss of the Rag2 C-terminus |pdf=|usr=}}{{26365182}} gab.com Text Off target V(D)J recombination drives lymphomagenesis and is escalated by loss of the Rag2 C-terminus JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26365182 #FOAvip Genome wide analysis of thymic lymphomas from Tp53?/? mice with wild-type or C-terminally truncated Rag2 revealed numerous off target, RAG-mediated DNA rearrangements. A significantly higher fraction of these errors mutated known and suspected oncogenes/tumor suppressor genes than did sporadic rearrangements (p<0.0001). This tractable mouse model recapitulates recent findings in human pre-B ALL and allows comparison of wild-type and mutant RAG2. Recurrent, RAG-mediated deletions affected Notch1, Pten, Ikzf1, Jak1, Phlda1, Trat1, and Agpat9. Rag2 truncation substantially increased the frequency of off target V(D)J recombination. The data suggest that interactions between Rag2 and a specific chromatin modification, H3K4me3, support V(D)J recombination fidelity. Oncogenic effects of off target rearrangements created by this highly regulated recombinase may need to be considered in design of site-specific nucleases engineered for genome modification. Twit Text FOAVip Off target V(D)J recombination drives lymphomagenesis and is escalated by loss of the Rag2 C-terminus ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26365182 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26365182 #FOAvip English Wikipedia <ref>{{Cite pmid|26365182}}</ref> Off target V(D)J recombination drives lymphomagenesis and is escalated by loss of the Rag2 C-terminus #MMPMID26365182 Miju?kovi? M; Chou YF; Gigi V; Lindsay CR; Shestova O; Lewis SM; Roth DB Cell Rep 2015[Sep]; 12 (11): 1842-52 PMID26365182show ga Genome wide analysis of thymic lymphomas from Tp53?/? mice with wild-type or C-terminally truncated Rag2 revealed numerous off target, RAG-mediated DNA rearrangements. A significantly higher fraction of these errors mutated known and suspected oncogenes/tumor suppressor genes than did sporadic rearrangements (p<0.0001). This tractable mouse model recapitulates recent findings in human pre-B ALL and allows comparison of wild-type and mutant RAG2. Recurrent, RAG-mediated deletions affected Notch1, Pten, Ikzf1, Jak1, Phlda1, Trat1, and Agpat9. Rag2 truncation substantially increased the frequency of off target V(D)J recombination. The data suggest that interactions between Rag2 and a specific chromatin modification, H3K4me3, support V(D)J recombination fidelity. Oncogenic effects of off target rearrangements created by this highly regulated recombinase may need to be considered in design of site-specific nucleases engineered for genome modification. äOff target V(D)J recombination drives lymphomagenesis and is escalated(epmc).pdf DeepDyve Pubget Overpricing