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pmid27725544      Intern+Med 2016 ; 55 (19): 2831-6
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  • Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis #MMPMID27725544
  • Sugawara Y; Honda K; Katagiri D; Nakamura M; Kawakami T; Nasu R; Hayashi A; Shintani Y; Tojo A; Noiri E; Kurokawa M; Fukayama M; Nangaku M
  • Intern Med 2016[Oct]; 55 (19): 2831-6 PMID27725544show ga
  • The development of nephrotic syndrome (NS) after umbilical cord transplantation (UBT) has been reported in only four cases to date. We herein report the case of a 50-year-old woman who developed NS 94 days after UBT. She fell into oliguria and required dialysis. A kidney biopsy revealed focal and segmental glomerulosclerosis. Although glucocorticoid monotherapy did not improve her condition, the addition of low-density lipoprotein (LDL) apheresis resulted in remission of NS, a drastic improvement in her renal function, and withdrawal from dialysis. To the best of our knowledge, this is the first report of UBT-associated NS treated with LDL apheresis.
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