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10.1126/science.aaa2151 http://scihub22266oqcxt.onion/10.1126/science.aaa2151 C5088503!5088503!25883361     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2015 ; 348 (6232): aaa2151 Nephropedia Template TP {{tp|p=25883361|t=2015. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential |pdf=|usr=}}{{25883361}} gab.com Text Identification and isolation of a dermal lineage with intrinsic fibrogenic potential JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=25883361 #FOAvip Dermal fibroblasts represent a heterogeneous population of cells with diverse features that remain largely undefined. We reveal the presence of at least two fibroblast lineages in murine dorsal skin. Lineage tracing and transplantation assays demonstrate that a single fibroblast lineage is responsible for the bulk of connective tissue deposition during embryonic development, cutaneous wound healing, radiation fibrosis, and cancer stroma formation. Lineage-specific cell ablation leads to diminished connective tissue deposition in wounds and reduces melanoma growth. Using flow cytometry, we identify CD26/DPP4 as a surface marker that allows isolation of this lineage. Small molecule?based inhibition of CD26/DPP4 enzymatic activity during wound healing results in diminished cutaneous scarring. Identification and isolation of these lineages hold promise for translational medicine aimed at in vivo modulation of fibrogenic behavior. Twit Text FOAVip Identification and isolation of a dermal lineage with intrinsic fibrogenic potential ????Science http://www.kidney.de/pget.php?&tw=1&pmid=25883361 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25883361 #FOAvip English Wikipedia <ref>{{Cite pmid|25883361}}</ref> Identification and isolation of a dermal lineage with intrinsic fibrogenic potential #MMPMID25883361 Rinkevich Y; Walmsley GG; Hu MS; Maan ZN; Newman AM; Drukker M; Januszyk M; Krampitz GW; Gurtner GC; Lorenz HP; Weissman IL; Longaker MT Science 2015[Apr]; 348 (6232): aaa2151 PMID25883361show ga Dermal fibroblasts represent a heterogeneous population of cells with diverse features that remain largely undefined. We reveal the presence of at least two fibroblast lineages in murine dorsal skin. Lineage tracing and transplantation assays demonstrate that a single fibroblast lineage is responsible for the bulk of connective tissue deposition during embryonic development, cutaneous wound healing, radiation fibrosis, and cancer stroma formation. Lineage-specific cell ablation leads to diminished connective tissue deposition in wounds and reduces melanoma growth. Using flow cytometry, we identify CD26/DPP4 as a surface marker that allows isolation of this lineage. Small molecule?based inhibition of CD26/DPP4 enzymatic activity during wound healing results in diminished cutaneous scarring. Identification and isolation of these lineages hold promise for translational medicine aimed at in vivo modulation of fibrogenic behavior. äIdentification and isolation of a dermal lineage with intrinsic fibrog(epmc).pdf DeepDyve Pubget Overpricing