Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1113/JP272419 http://scihub22266oqcxt.onion/10.1113/JP272419 C5088234!5088234!27350568     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27350568&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Physiol 2016 ; 594 (21): 6079-103 Nephropedia Template TP {{tp|p=27350568|t=2016. Pivotal role of ?2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease |pdf=|usr=}}{{27350568}} gab.com Text Pivotal role of 2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease JO: J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27350568 #FOAvip Reduced smooth muscle (SM)?specific ?2 Na+ pump expression elevates basal blood pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and dietary NaCl, whilst SM??2 overexpression lowers basal BP and decreases Ang II/salt sensitivity. Prolonged ouabain infusion induces hypertension in rodents, and ouabain?resistant mutation of the ?2 ouabain binding site (?2R/R mice) confers resistance to several forms of hypertension. Pressure overload?induced heart hypertrophy and failure are attenuated in cardio?specific ?2 knockout, cardio?specific ?2 overexpression and ?2R/R mice. We propose a unifying hypothesis that reconciles these apparently disparate findings: brain mechanisms, activated by Ang II and high NaCl, regulate sympathetic drive and a novel neurohumoral pathway mediated by both brain and circulating endogenous ouabain (EO). Circulating EO modulates ouabain?sensitive ?2 Na+ pump activity and Ca2+ transporter expression and, via Na+/Ca2+ exchange, Ca2+ homeostasis. This regulates sensitivity to sympathetic activity, Ca2+ signalling and arterial and cardiac contraction. Twit Text FOAVip Pivotal role of 2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease ????J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27350568 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27350568 #FOAvip English Wikipedia <ref>{{Cite pmid|27350568}}</ref> Pivotal role of ?2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease #MMPMID27350568 Blaustein MP; Chen L; Hamlyn JM; Leenen FHH; Lingrel JB; Wier WG; Zhang J J Physiol 2016[Nov]; 594 (21): 6079-103 PMID27350568show ga Reduced smooth muscle (SM)?specific ?2 Na+ pump expression elevates basal blood pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and dietary NaCl, whilst SM??2 overexpression lowers basal BP and decreases Ang II/salt sensitivity. Prolonged ouabain infusion induces hypertension in rodents, and ouabain?resistant mutation of the ?2 ouabain binding site (?2R/R mice) confers resistance to several forms of hypertension. Pressure overload?induced heart hypertrophy and failure are attenuated in cardio?specific ?2 knockout, cardio?specific ?2 overexpression and ?2R/R mice. We propose a unifying hypothesis that reconciles these apparently disparate findings: brain mechanisms, activated by Ang II and high NaCl, regulate sympathetic drive and a novel neurohumoral pathway mediated by both brain and circulating endogenous ouabain (EO). Circulating EO modulates ouabain?sensitive ?2 Na+ pump activity and Ca2+ transporter expression and, via Na+/Ca2+ exchange, Ca2+ homeostasis. This regulates sensitivity to sympathetic activity, Ca2+ signalling and arterial and cardiac contraction. äPivotal role of ?2 Na+ pumps and their high affinity ouabain binding s(epmc).pdf DeepDyve Pubget Overpricing