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10.1113/JP272419 http://scihub22266oqcxt.onion/10.1113/JP272419 C5088234!5088234 !27350568     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27350568 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Physiol 2016 ; 594 (21 ): 6079-6103 Nephropedia Template TP {{tp|p=27350568 |t=2016. Pivotal role of ?2 Na(+) pumps and their high affinity ouabain binding site in cardiovascular health and disease |pdf=|usr=}}{{27350568 }} gab.com Text Pivotal role of 2 Na(+) pumps and their high affinity ouabain binding site in cardiovascular health and disease JO: J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27350568 #FOAvip Reduced smooth muscle (SM)-specific ?2 Na(+) pump expression elevates basal blood pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and dietary NaCl, whilst SM-?2 overexpression lowers basal BP and decreases Ang II/salt sensitivity. Prolonged ouabain infusion induces hypertension in rodents, and ouabain-resistant mutation of the ?2 ouabain binding site (?2(R/R) mice) confers resistance to several forms of hypertension. Pressure overload-induced heart hypertrophy and failure are attenuated in cardio-specific ?2 knockout, cardio-specific ?2 overexpression and ?2(R/R) mice. We propose a unifying hypothesis that reconciles these apparently disparate findings: brain mechanisms, activated by Ang II and high NaCl, regulate sympathetic drive and a novel neurohumoral pathway mediated by both brain and circulating endogenous ouabain (EO). Circulating EO modulates ouabain-sensitive ?2 Na(+) pump activity and Ca(2+) transporter expression and, via Na(+) /Ca(2+) exchange, Ca(2+) homeostasis. This regulates sensitivity to sympathetic activity, Ca(2+) signalling and arterial and cardiac contraction. Twit Text FOAVip Pivotal role of 2 Na(+) pumps and their high affinity ouabain binding site in cardiovascular health and disease ????J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27350568 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27350568 #FOAvip English Wikipedia <ref>{{Cite pmid|27350568 }}</ref> Pivotal role of ?2 Na(+) pumps and their high affinity ouabain binding site in cardiovascular health and disease #MMPMID27350568 Blaustein MP ; Chen L ; Hamlyn JM ; Leenen FH ; Lingrel JB ; Wier WG ; Zhang J J Physiol 2016[Nov]; 594 (21 ): 6079-6103 PMID27350568 show ga Reduced smooth muscle (SM)-specific ?2 Na(+) pump expression elevates basal blood pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and dietary NaCl, whilst SM-?2 overexpression lowers basal BP and decreases Ang II/salt sensitivity. Prolonged ouabain infusion induces hypertension in rodents, and ouabain-resistant mutation of the ?2 ouabain binding site (?2(R/R) mice) confers resistance to several forms of hypertension. Pressure overload-induced heart hypertrophy and failure are attenuated in cardio-specific ?2 knockout, cardio-specific ?2 overexpression and ?2(R/R) mice. We propose a unifying hypothesis that reconciles these apparently disparate findings: brain mechanisms, activated by Ang II and high NaCl, regulate sympathetic drive and a novel neurohumoral pathway mediated by both brain and circulating endogenous ouabain (EO). Circulating EO modulates ouabain-sensitive ?2 Na(+) pump activity and Ca(2+) transporter expression and, via Na(+) /Ca(2+) exchange, Ca(2+) homeostasis. This regulates sensitivity to sympathetic activity, Ca(2+) signalling and arterial and cardiac contraction. |Angiotensins/metabolism [MESH] |Animals [MESH] |Binding Sites [MESH] |Cardiotonic Agents/pharmacology [MESH] |Cardiovascular System/drug effects/*metabolism [MESH] |Humans [MESH] |Hypertension/*metabolism/physiopathology [MESH] |Ouabain/*pharmacology [MESH] |Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors/chemistry/*metabolism [MESH]Pivotal role of ?2 Na(+) pumps and their high affinity ouabain binding(epmc).pdf DeepDyve Pubget Overpricing