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10.3389/fnmol.2016.00115 http://scihub22266oqcxt.onion/10.3389/fnmol.2016.00115 C5088202!5088202!27847465     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Mol+Neurosci 2016 ; 9 (ä): ä Nephropedia Template TP {{tp|p=27847465|t=2016. The Many Faces of Elongator in Neurodevelopment and Disease |pdf=|usr=}}{{27847465}} gab.com Text The Many Faces of Elongator in Neurodevelopment and Disease JO: Front Mol Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=27847465 #FOAvip Development of the nervous system requires a variety of cellular activities, such as proliferation, migration, axonal outgrowth and guidance and synapse formation during the differentiation of neural precursors into mature neurons. Malfunction of these highly regulated and coordinated events results in various neurological diseases. The Elongator complex is a multi-subunit complex highly conserved in eukaryotes whose function has been implicated in the majority of cellular activities underlying neurodevelopment. These activities include cell motility, actin cytoskeleton organization, exocytosis, polarized secretion, intracellular trafficking and the maintenance of neural function. Several studies have associated mutations in Elongator subunits with the neurological disorders familial dysautonomia (FD), intellectual disability (ID), amyotrophic lateral sclerosis (ALS) and rolandic epilepsy (RE). Here, we review the various cellular activities assigned to this complex and discuss the implications for neural development and disease. Further research in this area has the potential to generate new diagnostic tools, better prevention strategies and more effective treatment options for a wide variety of neurological disorders. Twit Text FOAVip The Many Faces of Elongator in Neurodevelopment and Disease ????Front Mol Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=27847465 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27847465 #FOAvip English Wikipedia <ref>{{Cite pmid|27847465}}</ref> The Many Faces of Elongator in Neurodevelopment and Disease #MMPMID27847465 Kojic M; Wainwright B Front Mol Neurosci 2016[]; 9 (ä): ä PMID27847465show ga Development of the nervous system requires a variety of cellular activities, such as proliferation, migration, axonal outgrowth and guidance and synapse formation during the differentiation of neural precursors into mature neurons. Malfunction of these highly regulated and coordinated events results in various neurological diseases. The Elongator complex is a multi-subunit complex highly conserved in eukaryotes whose function has been implicated in the majority of cellular activities underlying neurodevelopment. These activities include cell motility, actin cytoskeleton organization, exocytosis, polarized secretion, intracellular trafficking and the maintenance of neural function. Several studies have associated mutations in Elongator subunits with the neurological disorders familial dysautonomia (FD), intellectual disability (ID), amyotrophic lateral sclerosis (ALS) and rolandic epilepsy (RE). Here, we review the various cellular activities assigned to this complex and discuss the implications for neural development and disease. Further research in this area has the potential to generate new diagnostic tools, better prevention strategies and more effective treatment options for a wide variety of neurological disorders. äThe Many Faces of Elongator in Neurodevelopment and Disease (epmc).pdf DeepDyve Pubget Overpricing