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10.1080/2162402X.2016.1226719 http://scihub22266oqcxt.onion/10.1080/2162402X.2016.1226719 C5087297!5087297!27853649     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncoimmunology 2016 ; 5 (10): ä Nephropedia Template TP {{tp|p=27853649|t=2016. CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells |pdf=|usr=}}{{27853649}} gab.com Text CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27853649 #FOAvip CD24 expression has been implicated in the oncogenesis of multiple types of cancer and high tumor expression is considered a poor prognosis factor; however, the role of CD24 in oral cancer progression is unknown. Unlike other cancer types, we found that higher CD24 levels in human oral cancers are correlated to lower clinical stage and better overall survival. We then dissected the role of CD24 and mechanisms in oral cancer pathogenesis in mice using a genetic strategy and demonstrated that CD24 deficiency increased the oral cavity tumor burden in response to the carcinogen 4-nitroquioline 1-oxide (4-NQO). Immune profile analysis showed a significant expansion as well as increased suppressive function of myeloid-derived suppressor cells (MDSCs) in CD24?/? mice, but no apparent impairment in T cells, B cells, or dendritic cells. Further, studies with an orthotopically transplanted syngeneic squamous carcinoma model in the tongue of CD24?/? and CD24+/? mice confirmed the protective roles of CD24 against cancer. Moreover, the difference in tumor growth between CD24?/? and CD24+/? mice was blunted by immunodepletion of MDSCs. We conclude that CD24 expression impedes MDSC expansion and function, and thus slows oral cancer oncogenesis. This study is the first to examine the role of CD24 in a de novo oral cancer model, and it highlights the need to consider the immune regulatory roles of CD24 in the development of CD24-targeted therapy for cancer. Twit Text FOAVip CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=27853649 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27853649 #FOAvip English Wikipedia <ref>{{Cite pmid|27853649}}</ref> CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells #MMPMID27853649 Fugle CW; Zhang Y; Hong F; Sun S; Westwater C; Rachidi S; Yu H; Garret-Mayer E; Kirkwood K; Liu B; Li Z Oncoimmunology 2016[]; 5 (10): ä PMID27853649show ga CD24 expression has been implicated in the oncogenesis of multiple types of cancer and high tumor expression is considered a poor prognosis factor; however, the role of CD24 in oral cancer progression is unknown. Unlike other cancer types, we found that higher CD24 levels in human oral cancers are correlated to lower clinical stage and better overall survival. We then dissected the role of CD24 and mechanisms in oral cancer pathogenesis in mice using a genetic strategy and demonstrated that CD24 deficiency increased the oral cavity tumor burden in response to the carcinogen 4-nitroquioline 1-oxide (4-NQO). Immune profile analysis showed a significant expansion as well as increased suppressive function of myeloid-derived suppressor cells (MDSCs) in CD24?/? mice, but no apparent impairment in T cells, B cells, or dendritic cells. Further, studies with an orthotopically transplanted syngeneic squamous carcinoma model in the tongue of CD24?/? and CD24+/? mice confirmed the protective roles of CD24 against cancer. Moreover, the difference in tumor growth between CD24?/? and CD24+/? mice was blunted by immunodepletion of MDSCs. We conclude that CD24 expression impedes MDSC expansion and function, and thus slows oral cancer oncogenesis. This study is the first to examine the role of CD24 in a de novo oral cancer model, and it highlights the need to consider the immune regulatory roles of CD24 in the development of CD24-targeted therapy for cancer. äCD24 blunts oral squamous cancer development and dampens the functiona(epmc).pdf DeepDyve Pubget Overpricing