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10.1073/pnas.1608820113 http://scihub22266oqcxt.onion/10.1073/pnas.1608820113 C5087047!5087047!27702900     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (43): E6630-8 Nephropedia Template TP {{tp|p=27702900|t=2016. Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose |pdf=|usr=}}{{27702900}} gab.com Text Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27702900 #FOAvip T cells initiate and regulate adaptive immune responses when their T-cell antigen receptors recognize antigens. The T-cell response is known to depend on the antigen affinity/dose, but the precise relationship, and the mechanisms underlying it, are debated. To resolve the debate, we stimulated T cells with antigens spanning a 1 million-fold range in affinity/dose. We found that a different antigen (and hence different affinity) produced the largest T-cell response at different doses. Using model identification algorithms, we report a simple mechanistic model that can predict the T-cell response from the physiological low-affinity regime into the high-affinity regime applicable to therapeutic receptors. Twit Text FOAVip Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27702900 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27702900 #FOAvip English Wikipedia <ref>{{Cite pmid|27702900}}</ref> Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose #MMPMID27702900 Lever M; Lim HS; Kruger P; Nguyen J; Trendel N; Abu-Shah E; Maini PK; van der Merwe PA; Dushek O Proc Natl Acad Sci U S A 2016[Oct]; 113 (43): E6630-8 PMID27702900show ga T cells initiate and regulate adaptive immune responses when their T-cell antigen receptors recognize antigens. The T-cell response is known to depend on the antigen affinity/dose, but the precise relationship, and the mechanisms underlying it, are debated. To resolve the debate, we stimulated T cells with antigens spanning a 1 million-fold range in affinity/dose. We found that a different antigen (and hence different affinity) produced the largest T-cell response at different doses. Using model identification algorithms, we report a simple mechanistic model that can predict the T-cell response from the physiological low-affinity regime into the high-affinity regime applicable to therapeutic receptors. äArchitecture of a minimal signaling pathway explains the T-cell respon(epmc).pdf DeepDyve Pubget Overpricing