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10.1073/pnas.1608820113 http://scihub22266oqcxt.onion/10.1073/pnas.1608820113 C5087047!5087047 !27702900     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27702900 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (43 ): E6630-E6638 Nephropedia Template TP {{tp|p=27702900 |t=2016. Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose |pdf=|usr=}}{{27702900 }} gab.com Text Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27702900 #FOAvip T cells must respond differently to antigens of varying affinity presented at different doses. Previous attempts to map peptide MHC (pMHC) affinity onto T-cell responses have produced inconsistent patterns of responses, preventing formulations of canonical models of T-cell signaling. Here, a systematic analysis of T-cell responses to 1 million-fold variations in both pMHC affinity and dose produced bell-shaped dose-response curves and different optimal pMHC affinities at different pMHC doses. Using sequential model rejection/identification algorithms, we identified a unique, minimal model of cellular signaling incorporating kinetic proofreading with limited signaling coupled to an incoherent feed-forward loop (KPL-IFF) that reproduces these observations. We show that the KPL-IFF model correctly predicts the T-cell response to antigen copresentation. Our work offers a general approach for studying cellular signaling that does not require full details of biochemical pathways. Twit Text FOAVip Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27702900 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27702900 #FOAvip English Wikipedia <ref>{{Cite pmid|27702900 }}</ref> Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose #MMPMID27702900 Lever M ; Lim HS ; Kruger P ; Nguyen J ; Trendel N ; Abu-Shah E ; Maini PK ; van der Merwe PA ; Dushek O Proc Natl Acad Sci U S A 2016[Oct]; 113 (43 ): E6630-E6638 PMID27702900 show ga T cells must respond differently to antigens of varying affinity presented at different doses. Previous attempts to map peptide MHC (pMHC) affinity onto T-cell responses have produced inconsistent patterns of responses, preventing formulations of canonical models of T-cell signaling. Here, a systematic analysis of T-cell responses to 1 million-fold variations in both pMHC affinity and dose produced bell-shaped dose-response curves and different optimal pMHC affinities at different pMHC doses. Using sequential model rejection/identification algorithms, we identified a unique, minimal model of cellular signaling incorporating kinetic proofreading with limited signaling coupled to an incoherent feed-forward loop (KPL-IFF) that reproduces these observations. We show that the KPL-IFF model correctly predicts the T-cell response to antigen copresentation. Our work offers a general approach for studying cellular signaling that does not require full details of biochemical pathways. |*Models, Immunological [MESH] |Brefeldin A/pharmacology [MESH] |Dose-Response Relationship, Immunologic [MESH] |Gene Expression Regulation [MESH] |HLA-A2 Antigen/genetics/*immunology/pharmacology [MESH] |Humans [MESH] |Interferon-gamma/pharmacology [MESH] |Interleukin-2/pharmacology [MESH] |Jurkat Cells [MESH] |Kinetics [MESH] |Lymphocyte Activation/drug effects [MESH] |Phosphorylation [MESH] |Primary Cell Culture [MESH] |Protein Binding [MESH] |Receptors, Antigen, T-Cell/genetics/*immunology [MESH] |Recombinant Proteins/genetics/immunology/pharmacology [MESH] |Signal Transduction/*immunology [MESH] |T-Lymphocytes/cytology/drug effects/*immunology [MESH]Architecture of a minimal signaling pathway explains the T-cell respon(epmc).pdf DeepDyve Pubget Overpricing