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10.1073/pnas.1614042113 http://scihub22266oqcxt.onion/10.1073/pnas.1614042113 C5087030!5087030!27791016     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (43): 12280-5 Nephropedia Template TP {{tp|p=27791016|t=2016. Identification of the SNARE complex mediating the exocytosis of NMDA receptors |pdf=|usr=}}{{27791016}} gab.com Text Identification of the SNARE complex mediating the exocytosis of NMDA receptors JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27791016 #FOAvip NMDA receptors are ionotropic glutamate receptors and crucial for excitatory synaptic transmissions in the brain. We studied the regulation of the exocytosis of NMDA receptors by directly visualizing their exocytic events in rat hippocampal neurons by using total internal reflection florescence microscopy (TIRFM). We characterized the constitutive exocytic events of NMDA receptors and identified the Rab proteins involved in the exocytosis. Moreover, combining the TIRFM and immunocytochemistry methods, we found that the SNAP25?VAMP1?syntaxin4 complex mediated the constitutive exocytosis of NMDA receptor and maintained the expression of NMDA receptors at both extrasynaptic and synaptic surfaces. These results suggest that the SNAP25?VAMP1?syntaxin4 complex is important for neural functions by mediating the delivery of NMDA receptors to the plasma membrane. Twit Text FOAVip Identification of the SNARE complex mediating the exocytosis of NMDA receptors ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27791016 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27791016 #FOAvip English Wikipedia <ref>{{Cite pmid|27791016}}</ref> Identification of the SNARE complex mediating the exocytosis of NMDA receptors #MMPMID27791016 Gu Y; Huganir RL Proc Natl Acad Sci U S A 2016[Oct]; 113 (43): 12280-5 PMID27791016show ga NMDA receptors are ionotropic glutamate receptors and crucial for excitatory synaptic transmissions in the brain. We studied the regulation of the exocytosis of NMDA receptors by directly visualizing their exocytic events in rat hippocampal neurons by using total internal reflection florescence microscopy (TIRFM). We characterized the constitutive exocytic events of NMDA receptors and identified the Rab proteins involved in the exocytosis. Moreover, combining the TIRFM and immunocytochemistry methods, we found that the SNAP25?VAMP1?syntaxin4 complex mediated the constitutive exocytosis of NMDA receptor and maintained the expression of NMDA receptors at both extrasynaptic and synaptic surfaces. These results suggest that the SNAP25?VAMP1?syntaxin4 complex is important for neural functions by mediating the delivery of NMDA receptors to the plasma membrane. äIdentification of the SNARE complex mediating the exocytosis of NMDA r(epmc).pdf DeepDyve Pubget Overpricing