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10.1073/pnas.1606050113 http://scihub22266oqcxt.onion/10.1073/pnas.1606050113 C5086995!5086995!27702895     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (43): E6639-48 Nephropedia Template TP {{tp|p=27702895|t=2016. Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination |pdf=|usr=}}{{27702895}} gab.com Text Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27702895 #FOAvip We explored the effect of nontraditional vaccine dosing profiles on antibody titers of vaccines and discovered that certain dosing profiles demonstrate >10-fold higher antibody production than the traditional single-dose prime?boost method. We also present a computational model that captures the experimental results and provides a mechanistic understanding of the biology behind the effectiveness of our strategy. This work has clinical significance in vaccine design because it is a simple method to increase the efficacy of subunit vaccines, which may lead to the development of efficacious vaccines for diseases such as HIV. Twit Text FOAVip Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27702895 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27702895 #FOAvip English Wikipedia <ref>{{Cite pmid|27702895}}</ref> Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination #MMPMID27702895 Tam HH; Melo MB; Kang M; Pelet JM; Ruda VM; Foley MH; Hu JK; Kumari S; Crampton J; Baldeon AD; Sanders RW; Moore JP; Crotty S; Langer R; Anderson DG; Chakraborty AK; Irvine DJ Proc Natl Acad Sci U S A 2016[Oct]; 113 (43): E6639-48 PMID27702895show ga We explored the effect of nontraditional vaccine dosing profiles on antibody titers of vaccines and discovered that certain dosing profiles demonstrate >10-fold higher antibody production than the traditional single-dose prime?boost method. We also present a computational model that captures the experimental results and provides a mechanistic understanding of the biology behind the effectiveness of our strategy. This work has clinical significance in vaccine design because it is a simple method to increase the efficacy of subunit vaccines, which may lead to the development of efficacious vaccines for diseases such as HIV. äSustained antigen availability during germinal center initiation enhan(epmc).pdf DeepDyve Pubget Overpricing