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10.1073/pnas.1613448113 http://scihub22266oqcxt.onion/10.1073/pnas.1613448113 C5086985!5086985!27791008     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (43): 12220-5 Nephropedia Template TP {{tp|p=27791008|t=2016. Differential roles of the RNases H in preventing chromosome instability |pdf=|usr=}}{{27791008}} gab.com Text Differential roles of the RNases H in preventing chromosome instability JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27791008 #FOAvip DNA damage can lead to chromosome instability and loss of genetic information, resulting in cell death or diseases such as cancer. One source of damage is DNA:RNA hybrids that form when RNA transcripts hybridize to homologous sequences in the genome. Cells from all branches of life possess two enzymes that can degrade DNA:RNA hybrids: RNase H1 and RNase H2. In this study we explore the differential functions of the RNase H1 and H2 in preventing chromosome instability in the model organism Saccharomyces cerevisiae. We present evidence that RNase H2 acts on hybrids genome-wide to prevent chromosome instability. In contrast, RNase H1 acts at a subset of hybrids to repress locus-restricted chromosome instability. Twit Text FOAVip Differential roles of the RNases H in preventing chromosome instability ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27791008 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27791008 #FOAvip English Wikipedia <ref>{{Cite pmid|27791008}}</ref> Differential roles of the RNases H in preventing chromosome instability #MMPMID27791008 Zimmer AD; Koshland D Proc Natl Acad Sci U S A 2016[Oct]; 113 (43): 12220-5 PMID27791008show ga DNA damage can lead to chromosome instability and loss of genetic information, resulting in cell death or diseases such as cancer. One source of damage is DNA:RNA hybrids that form when RNA transcripts hybridize to homologous sequences in the genome. Cells from all branches of life possess two enzymes that can degrade DNA:RNA hybrids: RNase H1 and RNase H2. In this study we explore the differential functions of the RNase H1 and H2 in preventing chromosome instability in the model organism Saccharomyces cerevisiae. We present evidence that RNase H2 acts on hybrids genome-wide to prevent chromosome instability. In contrast, RNase H1 acts at a subset of hybrids to repress locus-restricted chromosome instability. äDifferential roles of the RNases H in preventing chromosome instabilit(epmc).pdf DeepDyve Pubget Overpricing